Cyclandelate in diabetic neuropathy. A double-blind, placebo-controlled, randomized, cross-over study

J J Heimans, B Drukarch, I Matthaei, G A Iiff, F W Bertelsmann, R L Strijers, J Nauta

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Cyclandelate has the ability to improve the rheological properties of the blood and therefore may improve blood supply of peripheral nerves. Previous studies in diabetic neuropathy have shown beneficial effects of the drug. We performed a double-blind, placebo-controlled, cross-over study in 40 diabetic patients with cyclandelate in a dose of 1600 mg daily. Motor and sensory nerve conduction velocities, late responses, thermal discrimination thresholds, vibration perception thresholds and pain scores were studied. We were not able to show any positive effect of the drug and therefore conclude that cyclandelate is not effective in the treatment of diabetic neuropathy.

Original languageEnglish
Pages (from-to)483-6
Number of pages4
JournalActa neurologica Scandinavica
Issue number6
Publication statusPublished - Dec 1991


  • Adult
  • Aged
  • Clinical Trial
  • Cyclandelate
  • Diabetic Neuropathies
  • Double-Blind Method
  • Female
  • Follow-Up Studies
  • Humans
  • Journal Article
  • Male
  • Middle Aged
  • Neurologic Examination
  • Peroneal Nerve
  • Randomized Controlled Trial
  • Sensory Thresholds
  • Synaptic Transmission

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