TY - JOUR
T1 - Cystectomie en urinedeviatie bij interstitiële blaasafwijkingen
AU - Nieuwenhuijzen, Jakko A.
AU - van der Sluis, Tim M.
N1 - Funding Information: This work was supported by NCI, National Institutes of Health Grant R01CA181654 (to G. N. and M. G.). This work was also supported by the Athymic Animal and Preclinical Therapeutics and Cytometry, Imaging Microscopy Shared Resources of the Case Comprehensive Cancer Center Grant P30CA043703, and Icahn School of Medicine at Mount Sinai Micros-copy Core Grant P30CA196521. The Icahn School of Medicine at Mount Sinai has filed patents covering composition of matter on the small mole-cules disclosed herein for the treatment of human cancer and other dis-eases (International Application Numbers: PCT/US15/19770, PCT/US15/ 19764; and US Patent: US 9,540,358 B2). Mount Sinai is actively seeking commercial partners for the further development of the technology. G. N. has a financial interest in the commercialization of the technology. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: © 2023, The Author(s).
PY - 2023/3
Y1 - 2023/3
N2 - Aim of the study was to evaluate the available literature on the likelihood of success of urinary diversions with or without cystectomy in patients with bladder pain syndrome/interstitial cystitis. Three reviews were found, zero randomized trials. In the 21 selected case series 475 patients were included. The success rate of urinary diversion was 81%. Predictors for success (presence of Hunner’s lesion and small bladder capacity) could not be confirmed due to heterogeneity of the studies. Urinary diversion in combination with removal of the bladder increased the chance of success in 96% of cases if combined with cystectomy, in 75% after partial cystectomy and in 79% after urinary deviation without cystectomy. It can be concluded that hard scientific evidence for or against a urinary diversion in BPS/interstitial cystitis is not available, because the (pretty good) results in the case series are to be be considered in the light of (inclusion) bias. Therefore, therapeutic choices should still be made on an individual bases.
AB - Aim of the study was to evaluate the available literature on the likelihood of success of urinary diversions with or without cystectomy in patients with bladder pain syndrome/interstitial cystitis. Three reviews were found, zero randomized trials. In the 21 selected case series 475 patients were included. The success rate of urinary diversion was 81%. Predictors for success (presence of Hunner’s lesion and small bladder capacity) could not be confirmed due to heterogeneity of the studies. Urinary diversion in combination with removal of the bladder increased the chance of success in 96% of cases if combined with cystectomy, in 75% after partial cystectomy and in 79% after urinary deviation without cystectomy. It can be concluded that hard scientific evidence for or against a urinary diversion in BPS/interstitial cystitis is not available, because the (pretty good) results in the case series are to be be considered in the light of (inclusion) bias. Therefore, therapeutic choices should still be made on an individual bases.
KW - bladder pain syndrome
KW - cystectomy
KW - interstitial cystitis
KW - urinary diversion
UR - http://www.scopus.com/inward/record.url?scp=85149243633&partnerID=8YFLogxK
U2 - https://doi.org/10.1007/s13629-023-00384-3
DO - https://doi.org/10.1007/s13629-023-00384-3
M3 - Article
SN - 2211-3037
VL - 13
SP - 65
EP - 70
JO - Tijdschrift voor urologie
JF - Tijdschrift voor urologie
IS - 2-3
ER -