TY - JOUR
T1 - Synovial signal intensity on static contrast-enhanced MRI for evaluation of disease activity in juvenile idiopathic arthritis – A look at the bright side of the knee
AU - Verkuil, Floris
AU - van den Berg, J. Merlijn
AU - van Gulik, E. Charlotte
AU - Barendregt, Anouk M.
AU - Rashid, Amara Nassar-Sheikh
AU - Schonenberg-Meinema, Dieneke
AU - Dolman, Koert M.
AU - Kuijpers, Taco W.
AU - Maas, Mario
AU - Hemke, Robert
N1 - Funding Information: The authors are grateful for the research grant received from ReumaNederland (NR 13-1-402) and the support by MSK Synergy. The Dutch Arthritis Society and MSK Synergy were not involved in designing or conducting this study, did not have access to the data, and were not involved in data analysis or preparation of this manuscript. Funding Information: The authors are grateful for the research grant received from ReumaNederland ( NR 13-1-402 ) and the support by MSK Synergy . The Dutch Arthritis Society and MSK Synergy were not involved in designing or conducting this study, did not have access to the data, and were not involved in data analysis or preparation of this manuscript. Publisher Copyright: © 2022 The Authors
PY - 2022/6/1
Y1 - 2022/6/1
N2 - Background: Knowledge on the role of synovial signal intensity (SI) grading on static contrast-enhanced (CE) MRI of the knee for assessment of disease activity in juvenile idiopathic arthritis (JIA) is lacking. Objectives: To assess the value of synovial SI on static CE-MRI of the knee for evaluation of disease activity in children with JIA. Materials and methods: Children with clinically inactive and clinically active JIA who underwent static CE-MRI of the knee were included. Synovial SI was evaluated on post-contrast T1-weighted fat-saturated images using a 0.02 cm2 region of interest drawn in the area of the synovium that contained visually the highest SI. To control for potential time-dependent post-contrast enhancement variability, a ratio between the SI of the synovium to the musculus gastrocnemius was calculated. Results: We included 427 JIA patients (clinically inactive JIA: 150 [35,1%]; clinically active JIA: 277 [64.9%]), 65.3% female, with a mean age of 13.3 ± 3.2 years. Mean SI synovium-to-muscle ratio was 2.1 ± 0.7 in patients with clinically inactive JIA versus 2.2 ± 0.8 in patients with clinically active JIA. Subgroup analysis showed no significant difference in SI synovium-to-muscle ratio between JIA patients with clinically inactive disease and JIA patients with clinically active disease (p-value 0.22). Conclusions: Evaluation of the brightness of the synovium on static CE-MRI of the knee for assessment of JIA disease activity should be avoided, as this might lead to incorrect clinical conclusions.
AB - Background: Knowledge on the role of synovial signal intensity (SI) grading on static contrast-enhanced (CE) MRI of the knee for assessment of disease activity in juvenile idiopathic arthritis (JIA) is lacking. Objectives: To assess the value of synovial SI on static CE-MRI of the knee for evaluation of disease activity in children with JIA. Materials and methods: Children with clinically inactive and clinically active JIA who underwent static CE-MRI of the knee were included. Synovial SI was evaluated on post-contrast T1-weighted fat-saturated images using a 0.02 cm2 region of interest drawn in the area of the synovium that contained visually the highest SI. To control for potential time-dependent post-contrast enhancement variability, a ratio between the SI of the synovium to the musculus gastrocnemius was calculated. Results: We included 427 JIA patients (clinically inactive JIA: 150 [35,1%]; clinically active JIA: 277 [64.9%]), 65.3% female, with a mean age of 13.3 ± 3.2 years. Mean SI synovium-to-muscle ratio was 2.1 ± 0.7 in patients with clinically inactive JIA versus 2.2 ± 0.8 in patients with clinically active JIA. Subgroup analysis showed no significant difference in SI synovium-to-muscle ratio between JIA patients with clinically inactive disease and JIA patients with clinically active disease (p-value 0.22). Conclusions: Evaluation of the brightness of the synovium on static CE-MRI of the knee for assessment of JIA disease activity should be avoided, as this might lead to incorrect clinical conclusions.
KW - Juvenile idiopathic arthritis
KW - Magnetic resonance imaging
KW - Signal intensity
KW - Synovial membrane
UR - http://www.scopus.com/inward/record.url?scp=85126994223&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.clinimag.2022.03.016
DO - https://doi.org/10.1016/j.clinimag.2022.03.016
M3 - Article
C2 - 35339802
SN - 0899-7071
VL - 86
SP - 53
EP - 60
JO - Clinical imaging
JF - Clinical imaging
ER -