DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells

T. B. Geijtenbeek, D. S. Kwon, R. Torensma, S. J. van Vliet, G. C. van Duijnhoven, J. Middel, I. L. Cornelissen, H. S. Nottet, V. N. KewalRamani, D. R. Littman, C. G. Figdor, Y. van Kooyk

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Abstract

Dendritic cells (DC) capture microorganisms that enter peripheral mucosal tissues and then migrate to secondary lymphoid organs, where they present these in antigenic form to resting T cells and thus initiate adaptive immune responses. Here, we describe the properties of a DC-specific C-type lectin, DC-SIGN, that is highly expressed on DC present in mucosal tissues and binds to the HIV-1 envelope glycoprotein gp120. DC-SIGN does not function as a receptor for viral entry into DC but instead promotes efficient infection in trans of cells that express CD4 and chemokine receptors. We propose that DC-SIGN efficiently captures HIV-1 in the periphery and facilitates its transport to secondary lymphoid organs rich in T cells, to enhance infection in trans of these target cells
Original languageEnglish
Pages (from-to)587-597
Number of pages11
JournalCell
Volume100
Issue number5
DOIs
Publication statusPublished - 3 Mar 2000

Keywords

  • CD4 Antigens/physiology
  • CD4-Positive T-Lymphocytes/cytology
  • Cell Adhesion Molecules/physiology
  • Cell Movement
  • Cells, Cultured
  • Cervix Uteri/cytology
  • Coculture Techniques
  • Dendritic Cells/immunology
  • Female
  • HIV Envelope Protein gp120/metabolism
  • HIV Infections/transmission
  • HIV-1/physiology
  • Humans
  • Lectins/physiology
  • Lymph Nodes/cytology
  • Lymphoid Tissue/cytology
  • Macromolecular Substances
  • Male
  • Mucous Membrane/cytology
  • Receptors, CCR5/physiology
  • Receptors, HIV/physiology
  • Rectum/cytology
  • Transfection
  • Uterus/cytology

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