DC-SIGN: escape mechanism for pathogens

Yvette van Kooyk, Teunis B H Geijtenbeek

Research output: Contribution to journalReview articleAcademicpeer-review

768 Citations (Scopus)

Abstract

Dendritic cells (DCs) are crucial in the defence against pathogens. Invading pathogens are recognized by Toll-like receptors (TLRs) and receptors such as C-type lectins expressed on the surface of DCs. However, it is becoming evident that some pathogens, including viruses, such as HIV-1, and non-viral pathogens, such as Mycobacterium tuberculosis, subvert DC functions to escape immune surveillance by targeting the C-type lectin DC-SIGN (DC-specific intercellular adhesion molecule-grabbing nonintegrin). Notably, these pathogens misuse DC-SIGN by distinct mechanisms that either circumvent antigen processing or alter TLR-mediated signalling, skewing T-cell responses. This implies that adaptation of pathogens to target DC-SIGN might support pathogen survival.

Original languageEnglish
Pages (from-to)697-709
Number of pages13
JournalNature Reviews Immunology
Volume3
Issue number9
DOIs
Publication statusPublished - Sep 2003

Keywords

  • Animals
  • Antigen Presentation/immunology
  • Cell Adhesion Molecules/immunology
  • Dendritic Cells/immunology
  • HIV Infections/immunology
  • HIV-1/immunology
  • Humans
  • Lectins, C-Type/immunology
  • Models, Molecular
  • Mycobacterium tuberculosis/immunology
  • Receptors, Cell Surface/immunology
  • Tuberculosis/immunology

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