Abstract
Dendritic cells (DCs) are crucial in the defence against pathogens. Invading pathogens are recognized by Toll-like receptors (TLRs) and receptors such as C-type lectins expressed on the surface of DCs. However, it is becoming evident that some pathogens, including viruses, such as HIV-1, and non-viral pathogens, such as Mycobacterium tuberculosis, subvert DC functions to escape immune surveillance by targeting the C-type lectin DC-SIGN (DC-specific intercellular adhesion molecule-grabbing nonintegrin). Notably, these pathogens misuse DC-SIGN by distinct mechanisms that either circumvent antigen processing or alter TLR-mediated signalling, skewing T-cell responses. This implies that adaptation of pathogens to target DC-SIGN might support pathogen survival.
Original language | English |
---|---|
Pages (from-to) | 697-709 |
Number of pages | 13 |
Journal | Nature Reviews Immunology |
Volume | 3 |
Issue number | 9 |
DOIs | |
Publication status | Published - Sept 2003 |
Keywords
- Animals
- Antigen Presentation/immunology
- Cell Adhesion Molecules/immunology
- Dendritic Cells/immunology
- HIV Infections/immunology
- HIV-1/immunology
- Humans
- Lectins, C-Type/immunology
- Models, Molecular
- Mycobacterium tuberculosis/immunology
- Receptors, Cell Surface/immunology
- Tuberculosis/immunology