DC-SIGN Polymorphisms Associate with Risk of Hepatitis C Virus Infection Among Men who Have Sex with Men but not Among Injecting Drug Users

Gaby S. Steba, Sylvie M. Koekkoek, Joost W. Vanhommerig, Kees Brinkman, David Kwa, Jan T. M. van der Meer, Maria Prins, Ben Berkhout, Michael Tanck, William A. Paxton, Richard Molenkamp, Janke Schinkel

Research output: Contribution to journalReview articleAcademicpeer-review

7 Citations (Scopus)

Abstract

We aimed to identify whether genetic polymorphisms within L-SIGN or DC-SIGN correlate with hepatitis C virus (HCV) susceptibility. A men who have sex with men (MSM) and an injecting drug users (IDU) cohort of HCV cases and multiple-exposed uninfected controls were genotyped for numerous L-SIGN and DC-SIGN polymorphisms. DC-SIGN single nucleotide polymorphisms (SNPs) -139, -871, and -939 correlated with HCV acquisition in the MSM cohort only. When the same SNPs were introduced into a transcription activity assay they demonstrated a reduction in expression with predicted alteration in binding of transcription factors. DC-SIGN promoter SNPs correlated with risk of HCV acquisition via sexual but not IDU exposure, likely through modulation of mRNA expression levels
Original languageEnglish
Pages (from-to)353-357
JournalJournal of infectious diseases
Volume217
Issue number3
Early online date2017
DOIs
Publication statusPublished - 2018

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