DC-SIGN Polymorphisms Associate with Risk of Hepatitis C Virus Infection Among Men who Have Sex with Men but not Among Injecting Drug Users

Gaby S. Steba; Sylvie M. Koekkoek; Joost W. Vanhommerig; Kees Brinkman; David Kwa; Jan T. M. van der Meer; Maria Prins; Ben Berkhout; Michael Tanck; William A. Paxton; Richard Molenkamp; Janke Schinkel

doi:https://doi.org/10.1093/infdis/jix587

DC-SIGN Polymorphisms Associate with Risk of Hepatitis C Virus Infection Among Men who Have Sex with Men but not Among Injecting Drug Users

Gaby S. Steba, Sylvie M. Koekkoek, Joost W. Vanhommerig, Kees Brinkman, David Kwa, Jan T. M. van der Meer, Maria Prins, Ben Berkhout, Michael Tanck, William A. Paxton, Richard Molenkamp, Janke Schinkel

Research output: Contribution to journal › Review article › Academic › peer-review

7 Citations (Scopus)

Abstract

We aimed to identify whether genetic polymorphisms within L-SIGN or DC-SIGN correlate with hepatitis C virus (HCV) susceptibility. A men who have sex with men (MSM) and an injecting drug users (IDU) cohort of HCV cases and multiple-exposed uninfected controls were genotyped for numerous L-SIGN and DC-SIGN polymorphisms. DC-SIGN single nucleotide polymorphisms (SNPs) -139, -871, and -939 correlated with HCV acquisition in the MSM cohort only. When the same SNPs were introduced into a transcription activity assay they demonstrated a reduction in expression with predicted alteration in binding of transcription factors. DC-SIGN promoter SNPs correlated with risk of HCV acquisition via sexual but not IDU exposure, likely through modulation of mRNA expression levels

Original language	English
Pages (from-to)	353-357
Journal	Journal of infectious diseases
Volume	217
Issue number	3
Early online date	2017
DOIs	https://doi.org/10.1093/infdis/jix587
Publication status	Published - 2018

Access to Document

https://doi.org/10.1093/infdis/jix587

Cite this

Steba, G. S., Koekkoek, S. M., Vanhommerig, J. W., Brinkman, K., Kwa, D., van der Meer, J. T. M., Prins, M., Berkhout, B., Tanck, M., Paxton, W. A., Molenkamp, R., & Schinkel, J. (2018). DC-SIGN Polymorphisms Associate with Risk of Hepatitis C Virus Infection Among Men who Have Sex with Men but not Among Injecting Drug Users. Journal of infectious diseases, 217(3), 353-357. https://doi.org/10.1093/infdis/jix587

@article{b2e7034d9ebc40ffbb75a6b65df270fe,

title = "DC-SIGN Polymorphisms Associate with Risk of Hepatitis C Virus Infection Among Men who Have Sex with Men but not Among Injecting Drug Users",

abstract = "We aimed to identify whether genetic polymorphisms within L-SIGN or DC-SIGN correlate with hepatitis C virus (HCV) susceptibility. A men who have sex with men (MSM) and an injecting drug users (IDU) cohort of HCV cases and multiple-exposed uninfected controls were genotyped for numerous L-SIGN and DC-SIGN polymorphisms. DC-SIGN single nucleotide polymorphisms (SNPs) -139, -871, and -939 correlated with HCV acquisition in the MSM cohort only. When the same SNPs were introduced into a transcription activity assay they demonstrated a reduction in expression with predicted alteration in binding of transcription factors. DC-SIGN promoter SNPs correlated with risk of HCV acquisition via sexual but not IDU exposure, likely through modulation of mRNA expression levels",

author = "Steba, {Gaby S.} and Koekkoek, {Sylvie M.} and Vanhommerig, {Joost W.} and Kees Brinkman and David Kwa and {van der Meer}, {Jan T. M.} and Maria Prins and Ben Berkhout and Michael Tanck and Paxton, {William A.} and Richard Molenkamp and Janke Schinkel",

year = "2018",

doi = "https://doi.org/10.1093/infdis/jix587",

language = "English",

volume = "217",

pages = "353--357",

journal = "Journal of infectious diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "3",

}

Steba, GS , Koekkoek, SM, Vanhommerig, JW, Brinkman, K, Kwa, D, van der Meer, JTM , Prins, M , Berkhout, B , Tanck, M, Paxton, WA, Molenkamp, R & Schinkel, J 2018, 'DC-SIGN Polymorphisms Associate with Risk of Hepatitis C Virus Infection Among Men who Have Sex with Men but not Among Injecting Drug Users', Journal of infectious diseases, vol. 217, no. 3, pp. 353-357. https://doi.org/10.1093/infdis/jix587

TY - JOUR

T1 - DC-SIGN Polymorphisms Associate with Risk of Hepatitis C Virus Infection Among Men who Have Sex with Men but not Among Injecting Drug Users

AU - Steba, Gaby S.

AU - Koekkoek, Sylvie M.

AU - Vanhommerig, Joost W.

AU - Brinkman, Kees

AU - Kwa, David

AU - van der Meer, Jan T. M.

AU - Prins, Maria

AU - Berkhout, Ben

AU - Tanck, Michael

AU - Paxton, William A.

AU - Molenkamp, Richard

AU - Schinkel, Janke

PY - 2018

Y1 - 2018

N2 - We aimed to identify whether genetic polymorphisms within L-SIGN or DC-SIGN correlate with hepatitis C virus (HCV) susceptibility. A men who have sex with men (MSM) and an injecting drug users (IDU) cohort of HCV cases and multiple-exposed uninfected controls were genotyped for numerous L-SIGN and DC-SIGN polymorphisms. DC-SIGN single nucleotide polymorphisms (SNPs) -139, -871, and -939 correlated with HCV acquisition in the MSM cohort only. When the same SNPs were introduced into a transcription activity assay they demonstrated a reduction in expression with predicted alteration in binding of transcription factors. DC-SIGN promoter SNPs correlated with risk of HCV acquisition via sexual but not IDU exposure, likely through modulation of mRNA expression levels

AB - We aimed to identify whether genetic polymorphisms within L-SIGN or DC-SIGN correlate with hepatitis C virus (HCV) susceptibility. A men who have sex with men (MSM) and an injecting drug users (IDU) cohort of HCV cases and multiple-exposed uninfected controls were genotyped for numerous L-SIGN and DC-SIGN polymorphisms. DC-SIGN single nucleotide polymorphisms (SNPs) -139, -871, and -939 correlated with HCV acquisition in the MSM cohort only. When the same SNPs were introduced into a transcription activity assay they demonstrated a reduction in expression with predicted alteration in binding of transcription factors. DC-SIGN promoter SNPs correlated with risk of HCV acquisition via sexual but not IDU exposure, likely through modulation of mRNA expression levels

U2 - https://doi.org/10.1093/infdis/jix587

DO - https://doi.org/10.1093/infdis/jix587

M3 - Review article

C2 - 29140443

SN - 0022-1899

VL - 217

SP - 353

EP - 357

JO - Journal of infectious diseases

JF - Journal of infectious diseases

IS - 3

ER -