Intraoperative detection of colorectal and pancreatic liver metastases using SGM-101, a fluorescent antibody targeting CEA

Ruben P. J. Meijer, Kim S. de Valk, Marion M. Deken, Leonora S. F. Boogerd, Charlotte E. S. Hoogstins, Shadhvi S. Bhairosingh, Rutger-Jan Swijnenburg, Bert A. Bonsing, B. rénice Framery, Arantza Fariña Sarasqueta, Hein Putter, Denise E. Hilling, Jacobus Burggraaf, Françoise Cailler, J. Sven D. Mieog, Alexander L. Vahrmeijer

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15 Citations (Scopus)

Abstract

Background: Fluorescence-guided surgery can provide surgeons with an imaging tool for real-time intraoperative tumor detection. SGM-101, an anti-CEA antibody labelled with a fluorescent dye, is a tumor-specific imaging agent that can aid in improving detection and complete resection for CEA-positive tumors. In this study, the performance of SGM-101 for the detection of colorectal and pancreatic liver metastases was investigated. Methods: In this open-label, non-randomized, single-arm pilot study, patients were included with liver metastases from colorectal origin and intraoperatively detected liver metastases from pancreatic origin (during planned pancreatic surgery). SGM-101 was administered two to four days before the scheduled surgery as a single intravenous injection. Intraoperative fluorescence imaging was performed using the Quest Spectrum® imaging system. The performance of SGM-101 was assessed by measuring the intraoperative fluorescence signal and comparing this to histopathology. Results: A total of 19 lesions were found in 11 patients, which were all suspected as malignant in white light and subsequent fluorescence inspection. Seventeen lesions were malignant with a mean tumor-to-background ratio of 1.7. The remaining two lesions were false-positives as proven by histology. Conclusion: CEA-targeted fluorescence-guided intraoperative tumor detection with SGM-101 is feasible for the detection of colorectal and pancreatic liver metastases.
Original languageEnglish
Pages (from-to)667-673
Number of pages7
JournalEuropean Journal of Surgical Oncology
Volume47
Issue number3
DOIs
Publication statusPublished - Mar 2021

Keywords

  • Colorectal cancer
  • Fluorescence-guided surgery
  • Liver metastases
  • Pancreatic cancer

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