De relatie tussen atherosclerose, cognitieve achteruitgang en depressie bij ouderen

Translated title of the contribution: The relationship between atherosclerosis, cognitive impairment, and depression in old age

D. J. Vinkers, R. C. Van Der Mast, M. L. Stek, R. G.J. Westendorp, J. Gussekloo

Research output: Contribution to JournalReview articleProfessional

4 Citations (Scopus)

Abstract

It has been suggested in the literature that atherosclerosis is a common causal pathway of cognitive impairment and late-onset depression, which may explain their co-occurrence in old age. In both the 'Leiden 85-plus Study' and the literature, strong evidence is found for a causal relationship between atherosclerosis and cognitive impairment, but there is less evidence for a causal relationship between atherosclerosis and late-onset depression. In the 'Leiden 85-plus Study', cognitive impairment was a risk factor for the development of late-onset depression, but depression in old age did not predict cognitive decline. This means that the prevention of atherosclerosis might prevent cognitive impairment and hence late-onset depression in old age.

Translated title of the contributionThe relationship between atherosclerosis, cognitive impairment, and depression in old age
Original languageDutch
Pages (from-to)2307-2311
Number of pages5
JournalNederlands Tijdschrift voor Geneeskunde
Volume150
Issue number42
Publication statusPublished - 21 Oct 2006

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