TY - JOUR
T1 - Decline of tuberculosis burden in vietnam measured by consecutive national surveys, 2007-2017
AU - Nguyen, Hai Viet
AU - Nguyen, Hoa Binh
AU - Nguyen, Nhung Viet
AU - Cobelens, Frank
AU - Finlay, Alyssa
AU - Dao, Cu Huy
AU - Mirtskhulava, Veriko
AU - Glaziou, Philippe
AU - Pham, Huyen T. T.
AU - de Haas, Petra
AU - Tiemersma, Edine
N1 - Funding Information: This study was funded by the Vietnam Ministry of Health; The Global Fund to Fight AIDS, Tuberculosis and Malaria; the US Agency for International Development; the US Centers for Disease Control and Prevention (CDC), Vietnam Office; the KNCV Tuberculosis Foundation; and the World Health Organization (WHO). CDC, KNCV, and WHO provided assistance in study design, data collection supervision, data analysis, and manuscript preparation. Publisher Copyright: © 2021 Centers for Disease Control and Prevention (CDC). All rights reserved.
PY - 2021/3/1
Y1 - 2021/3/1
N2 - Vietnam, a high tuberculosis (TB) burden country, conducted national TB prevalence surveys in 2007 and 2017. In both surveys participants were screened by using a questionnaire and chest radiograph; sputum samples were then collected to test for Mycobacterium tuberculosis by smear microscopy and Löwenstein-Jensen culture. Culture-positive, smear-positive, and smear-negative TB cases were defined by laboratory results, and the prevalence of tuberculosis was compared between the 2 surveys. The results showed prevalence of culture-positive TB decreased by 37% (95% CI 11.5%-55.4%), from 199 (95% CI 160-248) cases/100,000 adults in 2007 to 125 (95% CI 98-159) cases/100,000 adults in 2017. Prevalence of smear-positive TB dropped by 53% (95% CI 27.0%-69.7%), from 99 (95% CI 78-125) cases/100,000 adults to 46 (95% CI 32-68) cases/100,000 adults; smear-negative TB showed no substantial decrease. Replacing microscopy with molecular methods for primary diagnostics might enhance diagnosis of pulmonary TB cases and further lower TB burden.
AB - Vietnam, a high tuberculosis (TB) burden country, conducted national TB prevalence surveys in 2007 and 2017. In both surveys participants were screened by using a questionnaire and chest radiograph; sputum samples were then collected to test for Mycobacterium tuberculosis by smear microscopy and Löwenstein-Jensen culture. Culture-positive, smear-positive, and smear-negative TB cases were defined by laboratory results, and the prevalence of tuberculosis was compared between the 2 surveys. The results showed prevalence of culture-positive TB decreased by 37% (95% CI 11.5%-55.4%), from 199 (95% CI 160-248) cases/100,000 adults in 2007 to 125 (95% CI 98-159) cases/100,000 adults in 2017. Prevalence of smear-positive TB dropped by 53% (95% CI 27.0%-69.7%), from 99 (95% CI 78-125) cases/100,000 adults to 46 (95% CI 32-68) cases/100,000 adults; smear-negative TB showed no substantial decrease. Replacing microscopy with molecular methods for primary diagnostics might enhance diagnosis of pulmonary TB cases and further lower TB burden.
UR - http://www.scopus.com/inward/record.url?scp=85101622238&partnerID=8YFLogxK
U2 - https://doi.org/10.3201/eid2703.204253
DO - https://doi.org/10.3201/eid2703.204253
M3 - Article
C2 - 33622491
SN - 1080-6040
VL - 27
SP - 872
EP - 879
JO - Emerging infectious diseases
JF - Emerging infectious diseases
IS - 3
ER -