Decreased plasma orexin-A levels in obese individuals

J. A. Adam; P. P. C. A. Menheere; F. M. H. van Dielen; P. B. Soeters; W. A. Buurman; J. W. M. Greve

doi:https://doi.org/10.1038/sj.ijo.0801868

Decreased plasma orexin-A levels in obese individuals

J. A. Adam, P. P. C. A. Menheere, F. M. H. van Dielen, P. B. Soeters, W. A. Buurman, J. W. M. Greve

Research output: Contribution to journal › Article › Academic › peer-review

118 Citations (Scopus)

Abstract

Orexin-A and -B stimulate appetite and food intake in rats. Orexins and orexin receptors are present in the hypothalamus as well as the enteric nervous system, the pancreas and the gut. The presence of orexins in peripheral blood, however, has not yet been reported. To determine whether orexin-A is present in human plasma and is related to body weight, we measured plasma orexin-A and leptin levels in a population with a body mass index (BMI) range from 19.8 to 59 kg/m(2). Plasma orexin-A levels correlated negatively and plasma leptin levels correlated positively with BMI. In obese and morbidly obese individuals, orexin-A levels were significantly lower and leptin levels were significantly higher when compared to normal. Our results support previous data suggesting that orexin-A acts also in a peripheral manner. The fact that lower levels of plasma orexin-A are present in obese individuals suggests that it is involved in the regulation of human energy metabolism

Original language	English
Pages (from-to)	274-276
Journal	International journal of obesity (2005)
Volume	26
Issue number	2
DOIs	https://doi.org/10.1038/sj.ijo.0801868
Publication status	Published - 2002

Access to Document

https://doi.org/10.1038/sj.ijo.0801868

Cite this

@article{dd497bfc215448a8872ae164579dad5d,

title = "Decreased plasma orexin-A levels in obese individuals",

abstract = "Orexin-A and -B stimulate appetite and food intake in rats. Orexins and orexin receptors are present in the hypothalamus as well as the enteric nervous system, the pancreas and the gut. The presence of orexins in peripheral blood, however, has not yet been reported. To determine whether orexin-A is present in human plasma and is related to body weight, we measured plasma orexin-A and leptin levels in a population with a body mass index (BMI) range from 19.8 to 59 kg/m(2). Plasma orexin-A levels correlated negatively and plasma leptin levels correlated positively with BMI. In obese and morbidly obese individuals, orexin-A levels were significantly lower and leptin levels were significantly higher when compared to normal. Our results support previous data suggesting that orexin-A acts also in a peripheral manner. The fact that lower levels of plasma orexin-A are present in obese individuals suggests that it is involved in the regulation of human energy metabolism",

author = "Adam, {J. A.} and Menheere, {P. P. C. A.} and {van Dielen}, {F. M. H.} and Soeters, {P. B.} and Buurman, {W. A.} and Greve, {J. W. M.}",

year = "2002",

doi = "https://doi.org/10.1038/sj.ijo.0801868",

language = "English",

volume = "26",

pages = "274--276",

journal = "International journal of obesity (2005)",

issn = "0307-0565",

publisher = "Nature Publishing Group",

number = "2",

}

TY - JOUR

T1 - Decreased plasma orexin-A levels in obese individuals

AU - Adam, J. A.

AU - Menheere, P. P. C. A.

AU - van Dielen, F. M. H.

AU - Soeters, P. B.

AU - Buurman, W. A.

AU - Greve, J. W. M.

PY - 2002

Y1 - 2002

N2 - Orexin-A and -B stimulate appetite and food intake in rats. Orexins and orexin receptors are present in the hypothalamus as well as the enteric nervous system, the pancreas and the gut. The presence of orexins in peripheral blood, however, has not yet been reported. To determine whether orexin-A is present in human plasma and is related to body weight, we measured plasma orexin-A and leptin levels in a population with a body mass index (BMI) range from 19.8 to 59 kg/m(2). Plasma orexin-A levels correlated negatively and plasma leptin levels correlated positively with BMI. In obese and morbidly obese individuals, orexin-A levels were significantly lower and leptin levels were significantly higher when compared to normal. Our results support previous data suggesting that orexin-A acts also in a peripheral manner. The fact that lower levels of plasma orexin-A are present in obese individuals suggests that it is involved in the regulation of human energy metabolism

AB - Orexin-A and -B stimulate appetite and food intake in rats. Orexins and orexin receptors are present in the hypothalamus as well as the enteric nervous system, the pancreas and the gut. The presence of orexins in peripheral blood, however, has not yet been reported. To determine whether orexin-A is present in human plasma and is related to body weight, we measured plasma orexin-A and leptin levels in a population with a body mass index (BMI) range from 19.8 to 59 kg/m(2). Plasma orexin-A levels correlated negatively and plasma leptin levels correlated positively with BMI. In obese and morbidly obese individuals, orexin-A levels were significantly lower and leptin levels were significantly higher when compared to normal. Our results support previous data suggesting that orexin-A acts also in a peripheral manner. The fact that lower levels of plasma orexin-A are present in obese individuals suggests that it is involved in the regulation of human energy metabolism

U2 - https://doi.org/10.1038/sj.ijo.0801868

DO - https://doi.org/10.1038/sj.ijo.0801868

M3 - Article

C2 - 11850761

SN - 0307-0565

VL - 26

SP - 274

EP - 276

JO - International journal of obesity (2005)

JF - International journal of obesity (2005)

IS - 2

ER -