Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder

Martijn Figee, Judy Luigjes, Ruud Smolders, Carlos-Eduardo Valencia-Alfonso, Guido van Wingen, Bart de Kwaasteniet, Mariska Mantione, Pieter Ooms, Pelle de Koning, Nienke Vulink, Nina Levar, Lukas Droge, Pepijn van den Munckhof, P. Richard Schuurman, Aart Nederveen, Wim van den Brink, Ali Mazaheri, Matthijs Vink, Damiaan Denys

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322 Citations (Scopus)


Little is known about the underlying neural mechanism of deep brain stimulation (DBS). We found that DBS targeted at the nucleus accumbens (NAc) normalized NAc activity, reduced excessive connectivity between the NAc and prefrontal cortex, and decreased frontal low-frequency oscillations during symptom provocation in patients with obsessive-compulsive disorder. Our findings suggest that DBS is able to reduce maladaptive activity and connectivity of the stimulated region
Original languageEnglish
Pages (from-to)386-387
JournalNature neuroscience
Issue number4
Publication statusPublished - 2013

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