Deficient p75 low-affinity neurotrophin receptor expression exacerbates experimental allergic encephalomyelitis in C57/BL6 mice

Sjef Copray; Britta Küst; Bart Emmer; May Young Lin; Robert Liem; Sandra Amor; Helga de Vries; Sarah Floris; Erik Boddeke

doi:https://doi.org/10.1016/j.jneuroim.2003.11.008

Deficient p75 low-affinity neurotrophin receptor expression exacerbates experimental allergic encephalomyelitis in C57/BL6 mice

Sjef Copray, Britta Küst, Bart Emmer, May Young Lin, Robert Liem, Sandra Amor, Helga de Vries, Sarah Floris, Erik Boddeke

Research output: Contribution to journal › Article › Academic › peer-review

40 Citations (Scopus)

Abstract

We have investigated the role of p75NTR in inflammation in experimental allergic encephalomyelitis (EAE), a model for the human disease multiple sclerosis (MS). Induction of EAE in C57/BL6 wild-type mice resulted in expression of p75NTR in endothelial cells in the CNS. In contrast to the clinical manifestation of EAE observed in wild-type C57/BL6 mice, mice deficient for p75NTR (p75NTR knockout mice) developed severe or lethal disease and concomitant increased levels of inflammation in the CNS. Our findings suggest a physiological significant role for p75 NTR in CNS endothelial cells during inflammation and involvement in preservation of blood-brain barrier integrity during a severe infiltrative attack. © 2003 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	41-53
Number of pages	13
Journal	Journal of Neuroimmunology
Volume	148
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2003.11.008
Publication status	Published - Mar 2004

Keywords

Animals
Blood Vessels
CD11 Antigens
CD3 Complex
Central Nervous System
Comparative Study
Disease Models, Animal
Encephalomyelitis, Autoimmune, Experimental
Endothelial Cells
Gene Expression
Glycoproteins
Immunization
Immunohistochemistry
Journal Article
Mice
Mice, Inbred C57BL
Mice, Knockout
Microscopy, Electron
Multiple Sclerosis
Myelin-Oligodendrocyte Glycoprotein
Peptide Fragments
Probability
Receptor, Nerve Growth Factor
Receptors, Nerve Growth Factor
Research Support, Non-U.S. Gov't
Time Factors

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https://doi.org/10.1016/j.jneuroim.2003.11.008

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title = "Deficient p75 low-affinity neurotrophin receptor expression exacerbates experimental allergic encephalomyelitis in C57/BL6 mice",

abstract = "We have investigated the role of p75NTR in inflammation in experimental allergic encephalomyelitis (EAE), a model for the human disease multiple sclerosis (MS). Induction of EAE in C57/BL6 wild-type mice resulted in expression of p75NTR in endothelial cells in the CNS. In contrast to the clinical manifestation of EAE observed in wild-type C57/BL6 mice, mice deficient for p75NTR (p75NTR knockout mice) developed severe or lethal disease and concomitant increased levels of inflammation in the CNS. Our findings suggest a physiological significant role for p75 NTR in CNS endothelial cells during inflammation and involvement in preservation of blood-brain barrier integrity during a severe infiltrative attack. {\textcopyright} 2003 Elsevier B.V. All rights reserved.",

keywords = "Animals, Blood Vessels, CD11 Antigens, CD3 Complex, Central Nervous System, Comparative Study, Disease Models, Animal, Encephalomyelitis, Autoimmune, Experimental, Endothelial Cells, Gene Expression, Glycoproteins, Immunization, Immunohistochemistry, Journal Article, Mice, Mice, Inbred C57BL, Mice, Knockout, Microscopy, Electron, Multiple Sclerosis, Myelin-Oligodendrocyte Glycoprotein, Peptide Fragments, Probability, Receptor, Nerve Growth Factor, Receptors, Nerve Growth Factor, Research Support, Non-U.S. Gov't, Time Factors",

author = "Sjef Copray and Britta K{\"u}st and Bart Emmer and Lin, {May Young} and Robert Liem and Sandra Amor and {de Vries}, Helga and Sarah Floris and Erik Boddeke",

year = "2004",

month = mar,

doi = "https://doi.org/10.1016/j.jneuroim.2003.11.008",

language = "English",

volume = "148",

pages = "41--53",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier",

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AU - Copray, Sjef

AU - Küst, Britta

AU - Emmer, Bart

AU - Lin, May Young

AU - Liem, Robert

AU - Amor, Sandra

AU - de Vries, Helga

AU - Floris, Sarah

AU - Boddeke, Erik

PY - 2004/3

Y1 - 2004/3

N2 - We have investigated the role of p75NTR in inflammation in experimental allergic encephalomyelitis (EAE), a model for the human disease multiple sclerosis (MS). Induction of EAE in C57/BL6 wild-type mice resulted in expression of p75NTR in endothelial cells in the CNS. In contrast to the clinical manifestation of EAE observed in wild-type C57/BL6 mice, mice deficient for p75NTR (p75NTR knockout mice) developed severe or lethal disease and concomitant increased levels of inflammation in the CNS. Our findings suggest a physiological significant role for p75 NTR in CNS endothelial cells during inflammation and involvement in preservation of blood-brain barrier integrity during a severe infiltrative attack. © 2003 Elsevier B.V. All rights reserved.

AB - We have investigated the role of p75NTR in inflammation in experimental allergic encephalomyelitis (EAE), a model for the human disease multiple sclerosis (MS). Induction of EAE in C57/BL6 wild-type mice resulted in expression of p75NTR in endothelial cells in the CNS. In contrast to the clinical manifestation of EAE observed in wild-type C57/BL6 mice, mice deficient for p75NTR (p75NTR knockout mice) developed severe or lethal disease and concomitant increased levels of inflammation in the CNS. Our findings suggest a physiological significant role for p75 NTR in CNS endothelial cells during inflammation and involvement in preservation of blood-brain barrier integrity during a severe infiltrative attack. © 2003 Elsevier B.V. All rights reserved.

KW - Animals

KW - Blood Vessels

KW - CD11 Antigens

KW - CD3 Complex

KW - Central Nervous System

KW - Comparative Study

KW - Disease Models, Animal

KW - Encephalomyelitis, Autoimmune, Experimental

KW - Endothelial Cells

KW - Gene Expression

KW - Glycoproteins

KW - Immunization

KW - Immunohistochemistry

KW - Journal Article

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Knockout

KW - Microscopy, Electron

KW - Multiple Sclerosis

KW - Myelin-Oligodendrocyte Glycoprotein

KW - Peptide Fragments

KW - Probability

KW - Receptor, Nerve Growth Factor

KW - Receptors, Nerve Growth Factor

KW - Research Support, Non-U.S. Gov't

KW - Time Factors

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=1242295155&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/14975585

U2 - https://doi.org/10.1016/j.jneuroim.2003.11.008

DO - https://doi.org/10.1016/j.jneuroim.2003.11.008

M3 - Article

C2 - 14975585

SN - 0165-5728

VL - 148

SP - 41

EP - 53

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Deficient p75 low-affinity neurotrophin receptor expression exacerbates experimental allergic encephalomyelitis in C57/BL6 mice

Abstract

Keywords

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