Defining remission in childhood-onset lupus: PReS-endorsed consensus definitions by an international task force

E. M. D. Smith; A. Aggarwal; J. Ainsworth; E. Al-Abadi; T. Avcin; L. Bortey; J. Burnham; C. Ciurtin; C. M. Hedrich; S. Kamphuis; L. Lambert; D. M. Levy; L. Lewandowski; N. Maxwell; E. Morand; S. Özen; C. E. Pain; A. Ravelli; C. Saad Magalhaes; C. Pilkington; D. Schonenberg-Meinema; C. Scott; K. Tullus; M. W. Beresford; B. Goilav; N. Goss; L. Oni; on behalf of the International cSLE T2T Task Force

doi:10.1016/j.clim.2024.110214

Defining remission in childhood-onset lupus: PReS-endorsed consensus definitions by an international task force

E. M. D. Smith, A. Aggarwal, J. Ainsworth, E. Al-Abadi, T. Avcin, L. Bortey, J. Burnham, C. Ciurtin, C. M. Hedrich, S. Kamphuis, L. Lambert, D. M. Levy, L. Lewandowski, N. Maxwell, E. Morand, S. Özen, C. E. Pain, A. Ravelli, C. Saad Magalhaes, C. PilkingtonD. Schonenberg-Meinema, C. Scott, K. Tullus, M. W. Beresford, B. Goilav, N. Goss, L. Oni, on behalf of the International cSLE T2T Task Force

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objective: To derive childhood-onset SLE (cSLE) specific remission definitions for future treat-to-target (T2T) trials, observational studies, and clinical practice. Methods: The cSLE International T2T Task Force conducted Delphi surveys exploring paediatric perspectives on adult-onset SLE remission targets. A modified nominal group technique was used to discuss, refine, and agree on the cSLE remission target criteria. Results: The Task Force proposed two definitions of remission: ‘cSLE clinical remission on steroids (cCR)’ and ‘cSLE clinical remission off steroids (cCR-0)’. The common criteria are: (1) Clinical-SLEDAI-2 K = 0; (2) PGA score < 0.5 (0–3 scale); (4) stable antimalarials, immunosuppressive, and biologic therapy (changes due to side-effects, adherence, weight, or when building up to target dose allowed). Criterion (3) in cCR is the prednisolone dose ≤0.1 mg/kg/day (maximum 5 mg/day), whereas in cCR-0 it is zero. Conclusions: cSLE definitions of remission have been proposed, maintaining sufficient alignment with the adult-SLE definition to facilitate life-course research.

Original language	English
Article number	110214
Journal	Clinical Immunology
Volume	263
DOIs	https://doi.org/10.1016/j.clim.2024.110214
Publication status	Published - 1 Jun 2024

Keywords

Childhood-onset SLE
Remission
T2T
Treat-to-target
cSLE

Access to Document

10.1016/j.clim.2024.110214

Cite this

Smith, E. M. D., Aggarwal, A., Ainsworth, J., Al-Abadi, E., Avcin, T., Bortey, L., Burnham, J., Ciurtin, C., Hedrich, C. M., Kamphuis, S., Lambert, L., Levy, D. M., Lewandowski, L., Maxwell, N., Morand, E., Özen, S., Pain, C. E., Ravelli, A., Saad Magalhaes, C., ... on behalf of the International cSLE T2T Task Force (2024). Defining remission in childhood-onset lupus: PReS-endorsed consensus definitions by an international task force. Clinical Immunology, 263, Article 110214. https://doi.org/10.1016/j.clim.2024.110214

@article{eafb53c926e14351b4c02d72593d8c67,

title = "Defining remission in childhood-onset lupus: PReS-endorsed consensus definitions by an international task force",

abstract = "Objective: To derive childhood-onset SLE (cSLE) specific remission definitions for future treat-to-target (T2T) trials, observational studies, and clinical practice. Methods: The cSLE International T2T Task Force conducted Delphi surveys exploring paediatric perspectives on adult-onset SLE remission targets. A modified nominal group technique was used to discuss, refine, and agree on the cSLE remission target criteria. Results: The Task Force proposed two definitions of remission: {\textquoteleft}cSLE clinical remission on steroids (cCR){\textquoteright} and {\textquoteleft}cSLE clinical remission off steroids (cCR-0){\textquoteright}. The common criteria are: (1) Clinical-SLEDAI-2 K = 0; (2) PGA score < 0.5 (0–3 scale); (4) stable antimalarials, immunosuppressive, and biologic therapy (changes due to side-effects, adherence, weight, or when building up to target dose allowed). Criterion (3) in cCR is the prednisolone dose ≤0.1 mg/kg/day (maximum 5 mg/day), whereas in cCR-0 it is zero. Conclusions: cSLE definitions of remission have been proposed, maintaining sufficient alignment with the adult-SLE definition to facilitate life-course research.",

keywords = "Childhood-onset SLE, Remission, T2T, Treat-to-target, cSLE",

author = "Smith, {E. M. D.} and A. Aggarwal and J. Ainsworth and E. Al-Abadi and T. Avcin and L. Bortey and J. Burnham and C. Ciurtin and Hedrich, {C. M.} and S. Kamphuis and L. Lambert and Levy, {D. M.} and L. Lewandowski and N. Maxwell and E. Morand and S. {\"O}zen and Pain, {C. E.} and A. Ravelli and {Saad Magalhaes}, C. and C. Pilkington and D. Schonenberg-Meinema and C. Scott and K. Tullus and Beresford, {M. W.} and B. Goilav and N. Goss and L. Oni and {on behalf of the International cSLE T2T Task Force} and Marks, {S. D.}",

note = "Publisher Copyright: {\textcopyright} 2024 The Authors",

year = "2024",

month = jun,

day = "1",

doi = "10.1016/j.clim.2024.110214",

language = "English",

volume = "263",

journal = "Clinical Immunology",

issn = "1521-6616",

publisher = "Academic Press Inc.",

}

Smith, EMD, Aggarwal, A, Ainsworth, J, Al-Abadi, E, Avcin, T, Bortey, L, Burnham, J, Ciurtin, C, Hedrich, CM, Kamphuis, S, Lambert, L, Levy, DM, Lewandowski, L, Maxwell, N, Morand, E, Özen, S, Pain, CE, Ravelli, A, Saad Magalhaes, C, Pilkington, C, Schonenberg-Meinema, D, Scott, C, Tullus, K, Beresford, MW, Goilav, B, Goss, N, Oni, L & on behalf of the International cSLE T2T Task Force 2024, 'Defining remission in childhood-onset lupus: PReS-endorsed consensus definitions by an international task force', Clinical Immunology, vol. 263, 110214. https://doi.org/10.1016/j.clim.2024.110214

TY - JOUR

T1 - Defining remission in childhood-onset lupus

T2 - PReS-endorsed consensus definitions by an international task force

AU - Smith, E. M. D.

AU - Aggarwal, A.

AU - Ainsworth, J.

AU - Al-Abadi, E.

AU - Avcin, T.

AU - Bortey, L.

AU - Burnham, J.

AU - Ciurtin, C.

AU - Hedrich, C. M.

AU - Kamphuis, S.

AU - Lambert, L.

AU - Levy, D. M.

AU - Lewandowski, L.

AU - Maxwell, N.

AU - Morand, E.

AU - Özen, S.

AU - Pain, C. E.

AU - Ravelli, A.

AU - Saad Magalhaes, C.

AU - Pilkington, C.

AU - Schonenberg-Meinema, D.

AU - Scott, C.

AU - Tullus, K.

AU - Beresford, M. W.

AU - Goilav, B.

AU - Goss, N.

AU - Oni, L.

AU - on behalf of the International cSLE T2T Task Force

AU - Marks, S. D.

PY - 2024/6/1

Y1 - 2024/6/1

N2 - Objective: To derive childhood-onset SLE (cSLE) specific remission definitions for future treat-to-target (T2T) trials, observational studies, and clinical practice. Methods: The cSLE International T2T Task Force conducted Delphi surveys exploring paediatric perspectives on adult-onset SLE remission targets. A modified nominal group technique was used to discuss, refine, and agree on the cSLE remission target criteria. Results: The Task Force proposed two definitions of remission: ‘cSLE clinical remission on steroids (cCR)’ and ‘cSLE clinical remission off steroids (cCR-0)’. The common criteria are: (1) Clinical-SLEDAI-2 K = 0; (2) PGA score < 0.5 (0–3 scale); (4) stable antimalarials, immunosuppressive, and biologic therapy (changes due to side-effects, adherence, weight, or when building up to target dose allowed). Criterion (3) in cCR is the prednisolone dose ≤0.1 mg/kg/day (maximum 5 mg/day), whereas in cCR-0 it is zero. Conclusions: cSLE definitions of remission have been proposed, maintaining sufficient alignment with the adult-SLE definition to facilitate life-course research.

AB - Objective: To derive childhood-onset SLE (cSLE) specific remission definitions for future treat-to-target (T2T) trials, observational studies, and clinical practice. Methods: The cSLE International T2T Task Force conducted Delphi surveys exploring paediatric perspectives on adult-onset SLE remission targets. A modified nominal group technique was used to discuss, refine, and agree on the cSLE remission target criteria. Results: The Task Force proposed two definitions of remission: ‘cSLE clinical remission on steroids (cCR)’ and ‘cSLE clinical remission off steroids (cCR-0)’. The common criteria are: (1) Clinical-SLEDAI-2 K = 0; (2) PGA score < 0.5 (0–3 scale); (4) stable antimalarials, immunosuppressive, and biologic therapy (changes due to side-effects, adherence, weight, or when building up to target dose allowed). Criterion (3) in cCR is the prednisolone dose ≤0.1 mg/kg/day (maximum 5 mg/day), whereas in cCR-0 it is zero. Conclusions: cSLE definitions of remission have been proposed, maintaining sufficient alignment with the adult-SLE definition to facilitate life-course research.

KW - Childhood-onset SLE

KW - Remission

KW - T2T

KW - Treat-to-target

KW - cSLE

UR - http://www.scopus.com/inward/record.url?scp=85191445420&partnerID=8YFLogxK

U2 - 10.1016/j.clim.2024.110214

DO - 10.1016/j.clim.2024.110214

M3 - Article

C2 - 38604255

SN - 1521-6616

VL - 263

JO - Clinical Immunology

JF - Clinical Immunology

M1 - 110214

ER -

Defining remission in childhood-onset lupus: PReS-endorsed consensus definitions by an international task force

Abstract

Keywords

Access to Document

Other files and links

Cite this