Defining trained immunity and its role in health and disease

Mihai G. Netea; Jorge Domínguez-Andrés; Luis B. Barreiro; Triantafyllos Chavakis; Maziar Divangahi; Elaine Fuchs; Leo A. B. Joosten; Jos W. M. van der Meer; Musa M. Mhlanga; Willem J. M. Mulder; Niels P. Riksen; Andreas Schlitzer; Joachim L. Schultze; Christine Stabell Benn; Joseph C. Sun; Ramnik J. Xavier; Eicke Latz

doi:https://doi.org/10.1038/s41577-020-0285-6

Defining trained immunity and its role in health and disease

Mihai G. Netea, Jorge Domínguez-Andrés, Luis B. Barreiro, Triantafyllos Chavakis, Maziar Divangahi, Elaine Fuchs, Leo A. B. Joosten, Jos W. M. van der Meer, Musa M. Mhlanga, Willem J. M. Mulder, Niels P. Riksen, Andreas Schlitzer, Joachim L. Schultze, Christine Stabell Benn, Joseph C. Sun, Ramnik J. Xavier, Eicke Latz

Research output: Contribution to journal › Review article › Academic › peer-review

1223 Citations (Scopus)

Abstract

Immune memory is a defining feature of the acquired immune system, but activation of the innate immune system can also result in enhanced responsiveness to subsequent triggers. This process has been termed ‘trained immunity’, a de facto innate immune memory. Research in the past decade has pointed to the broad benefits of trained immunity for host defence but has also suggested potentially detrimental outcomes in immune-mediated and chronic inflammatory diseases. Here we define ‘trained immunity’ as a biological process and discuss the innate stimuli and the epigenetic and metabolic reprogramming events that shape the induction of trained immunity.

Original language	English
Pages (from-to)	375-388
Number of pages	14
Journal	Nature Reviews. Immunology
Volume	20
Issue number	6
DOIs	https://doi.org/10.1038/s41577-020-0285-6
Publication status	Published - 1 Jun 2020

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Netea, M. G., Domínguez-Andrés, J., Barreiro, L. B., Chavakis, T., Divangahi, M., Fuchs, E., Joosten, L. A. B., van der Meer, J. W. M., Mhlanga, M. M., Mulder, W. J. M., Riksen, N. P., Schlitzer, A., Schultze, J. L., Stabell Benn, C., Sun, J. C., Xavier, R. J., & Latz, E. (2020). Defining trained immunity and its role in health and disease. Nature Reviews. Immunology, 20(6), 375-388. https://doi.org/10.1038/s41577-020-0285-6

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title = "Defining trained immunity and its role in health and disease",

abstract = "Immune memory is a defining feature of the acquired immune system, but activation of the innate immune system can also result in enhanced responsiveness to subsequent triggers. This process has been termed {\textquoteleft}trained immunity{\textquoteright}, a de facto innate immune memory. Research in the past decade has pointed to the broad benefits of trained immunity for host defence but has also suggested potentially detrimental outcomes in immune-mediated and chronic inflammatory diseases. Here we define {\textquoteleft}trained immunity{\textquoteright} as a biological process and discuss the innate stimuli and the epigenetic and metabolic reprogramming events that shape the induction of trained immunity.",

author = "Netea, {Mihai G.} and Jorge Dom{\'i}nguez-Andr{\'e}s and Barreiro, {Luis B.} and Triantafyllos Chavakis and Maziar Divangahi and Elaine Fuchs and Joosten, {Leo A. B.} and {van der Meer}, {Jos W. M.} and Mhlanga, {Musa M.} and Mulder, {Willem J. M.} and Riksen, {Niels P.} and Andreas Schlitzer and Schultze, {Joachim L.} and {Stabell Benn}, Christine and Sun, {Joseph C.} and Xavier, {Ramnik J.} and Eicke Latz",

year = "2020",

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doi = "https://doi.org/10.1038/s41577-020-0285-6",

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Netea, MG, Domínguez-Andrés, J, Barreiro, LB, Chavakis, T, Divangahi, M, Fuchs, E, Joosten, LAB, van der Meer, JWM, Mhlanga, MM, Mulder, WJM, Riksen, NP, Schlitzer, A, Schultze, JL, Stabell Benn, C, Sun, JC, Xavier, RJ & Latz, E 2020, 'Defining trained immunity and its role in health and disease', Nature Reviews. Immunology, vol. 20, no. 6, pp. 375-388. https://doi.org/10.1038/s41577-020-0285-6

TY - JOUR

T1 - Defining trained immunity and its role in health and disease

AU - Netea, Mihai G.

AU - Domínguez-Andrés, Jorge

AU - Barreiro, Luis B.

AU - Chavakis, Triantafyllos

AU - Divangahi, Maziar

AU - Fuchs, Elaine

AU - Joosten, Leo A. B.

AU - van der Meer, Jos W. M.

AU - Mhlanga, Musa M.

AU - Mulder, Willem J. M.

AU - Riksen, Niels P.

AU - Schlitzer, Andreas

AU - Schultze, Joachim L.

AU - Stabell Benn, Christine

AU - Sun, Joseph C.

AU - Xavier, Ramnik J.

AU - Latz, Eicke

PY - 2020/6/1

Y1 - 2020/6/1

N2 - Immune memory is a defining feature of the acquired immune system, but activation of the innate immune system can also result in enhanced responsiveness to subsequent triggers. This process has been termed ‘trained immunity’, a de facto innate immune memory. Research in the past decade has pointed to the broad benefits of trained immunity for host defence but has also suggested potentially detrimental outcomes in immune-mediated and chronic inflammatory diseases. Here we define ‘trained immunity’ as a biological process and discuss the innate stimuli and the epigenetic and metabolic reprogramming events that shape the induction of trained immunity.

AB - Immune memory is a defining feature of the acquired immune system, but activation of the innate immune system can also result in enhanced responsiveness to subsequent triggers. This process has been termed ‘trained immunity’, a de facto innate immune memory. Research in the past decade has pointed to the broad benefits of trained immunity for host defence but has also suggested potentially detrimental outcomes in immune-mediated and chronic inflammatory diseases. Here we define ‘trained immunity’ as a biological process and discuss the innate stimuli and the epigenetic and metabolic reprogramming events that shape the induction of trained immunity.

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U2 - https://doi.org/10.1038/s41577-020-0285-6

DO - https://doi.org/10.1038/s41577-020-0285-6

M3 - Review article

C2 - 32132681

SN - 1474-1733

VL - 20

SP - 375

EP - 388

JO - Nature Reviews. Immunology

JF - Nature Reviews. Immunology

IS - 6

ER -

Defining trained immunity and its role in health and disease

Abstract

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