@article{ca962ce404734943b01f4ce2a277c79b,
title = "Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study",
abstract = "Antibody-based therapeutics and vaccines are essential to combat COVID-19 morbidity and mortality after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Multiple mutations in SARS-CoV-2 that could impair antibody defenses propagated in human-to-human transmission and spillover or spillback events between humans and animals. To develop prevention and therapeutic strategies, we formed an international consortium to map the epitope landscape on the SARS-CoV-2 spike protein, defining and structurally illustrating seven receptor binding domain (RBD)–directed antibody communities with distinct footprints and competition profiles. Pseudovirion-based neutralization assays reveal spike mutations, individually and clustered together in variants, that affect antibody function among the communities. Key classes of RBD-targeted antibodies maintain neutralization activity against these emerging SARS-CoV-2 variants. These results provide a framework for selecting antibody treatment cocktails and understanding how viral variants might affect antibody therapeutic efficacy.",
author = "{CoVIC-DB team} and Hastie, {Kathryn M.} and Haoyang Li and Daniel Bedinger and Schendel, {Sharon L.} and {Moses Dennison}, S. and Kan Li and Vamseedhar Rayaprolu and Xiaoying Yu and Colin Mann and Michelle Zandonatti and Avalos, {Ruben Diaz} and Dawid Zyla and Tierra Buck and Sean Hui and Kelly Shaffer and Chitra Hariharan and Jieyun Yin and Eduardo Olmedillas and Adrian Enriquez and Diptiben Parekh and Milite Abraha and Elizabeth Feeney and Horn, {Gillian Q.} and Yoann Aldon and Hanif Ali and Sanja Aracic and Cobb, {Ronald R.} and Federman, {Ross S.} and Fernandez, {Joseph M.} and Jacob Glanville and Robin Green and Gevorg Grigoryan and {Lujan Hernandez}, {Ana G.} and Ho, {David D.} and Huang, {Kuan-Ying A.} and John Ingraham and Weidong Jiang and Paul Kellam and Cheolmin Kim and Minsoo Kim and Kim, {Hyeong Mi} and Chao Kong and Krebs, {Shelly J.} and Fei Lan and Guojun Lang and Sooyoung Lee and Leung, {Cheuk Lun} and Sanders, {Rogier W.} and Snitselaar, {Jonne L.} and {van Gils}, {Marit J.}",
note = "Funding Information: We gratefully acknowledge philanthropic support of the Overton family for this urgent study (Coronavirus Immunotherapeutic Consortium), COVID-19 Therapeutics Accelerator INV-006133 (Coronavirus Immunotherapeutic Consortium), Bill and Melinda Gates Foundation OPP1210938 (Coronavirus Immunotherapeutic Consortium), GHR Foundation (Coronavirus Immunotherapeutic Consortium), and NIH/NIAID grant U19 AI142790-S1 (Coronavirus Immunotherapeutic Consortium). We also acknowledge philanthropic support of C. Lee, FastGrants from Emergent Ventures at the Mercatus Center, George Mason University for support of essential instrumentation, and T.S. for support of the Saphire laboratory efforts during the pandemic (E.O.S.); Early Postdoc Mobility Fellowship of the Swiss National Science Foundation P2EZP3_195680 (D.Z.); and Translating Duke Health Immunology Initiative (G.T.). Publisher Copyright: {\textcopyright} 2021 American Association for the Advancement of Science. All rights reserved.",
year = "2021",
month = oct,
day = "22",
doi = "https://doi.org/10.1126/science.abh2315",
language = "English",
volume = "374",
pages = "478--472",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6566",
}