TY - JOUR
T1 - Dendritic Cell Subsets in Oral Mucosa of Allergic and Healthy Subjects
AU - Reinartz, Susanne M.
AU - van Tongeren, Joost
AU - van Egmond, Danielle
AU - de Groot, Esther J. J.
AU - Fokkens, Wytske J.
AU - van Drunen, Cornelis M.
PY - 2016
Y1 - 2016
N2 - Immunohistochemistry was used to identify, enumerate, and describe the tissue distribution of Langerhans type (CD1a and CD207), myeloid (CD1c and CD141), and plasmacytoid (CD303 and CD304) dendritic cell subsets in oral mucosa of allergic and non-allergic individuals. Allergic individuals have more CD141+ myeloid cells in epithelium and more CD1a+ Langerhans cells in the lamina propria compared to healthy controls, but similar numbers for the other DC subtypes. Our data are the first to describe the presence of CD303+ plasmacytoid DCs in human oral mucosa and a dense intraepithelial network of CD141+ DCs. The number of Langerhans type DCs (CD1a and CD207) and myeloid DCs (CD1c), was higher in the oral mucosa than in the nasal mucosa of the same individual independent of the atopic status
AB - Immunohistochemistry was used to identify, enumerate, and describe the tissue distribution of Langerhans type (CD1a and CD207), myeloid (CD1c and CD141), and plasmacytoid (CD303 and CD304) dendritic cell subsets in oral mucosa of allergic and non-allergic individuals. Allergic individuals have more CD141+ myeloid cells in epithelium and more CD1a+ Langerhans cells in the lamina propria compared to healthy controls, but similar numbers for the other DC subtypes. Our data are the first to describe the presence of CD303+ plasmacytoid DCs in human oral mucosa and a dense intraepithelial network of CD141+ DCs. The number of Langerhans type DCs (CD1a and CD207) and myeloid DCs (CD1c), was higher in the oral mucosa than in the nasal mucosa of the same individual independent of the atopic status
U2 - https://doi.org/10.1371/journal.pone.0154409
DO - https://doi.org/10.1371/journal.pone.0154409
M3 - Article
C2 - 27166951
SN - 1932-6203
VL - 11
SP - e0154409
JO - PLOS ONE
JF - PLOS ONE
IS - 5
ER -