Abstract
| Original language | English |
|---|---|
| Article number | 103659 |
| Journal | Critical Reviews in Oncology/Hematology |
| Volume | 173 |
| DOIs |
|
| Publication status | Published - 1 May 2022 |
Keywords
- AXL
- Diagnosis
- Liquid biopsies
- Pancreatic cancer
Access to Document
Other files and links
Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver
}
In: Critical Reviews in Oncology/Hematology, Vol. 173, 103659, 01.05.2022.
Research output: Contribution to journal › Comment/Letter to the editor › Academic
TY - JOUR
T1 - “Depart from evil, and do good”
T2 - Turning Axl from uncontrolled tumorigenic gene to biomarker for early detection of pancreatic cancer
AU - Comandatore, Annalisa
AU - Balsano, Rita
AU - Immordino, Benoit
AU - Arguedas, Davinia
AU - Capula, Mjriam
AU - Baglio, Serena R.
AU - Garajovà, Ingrid
AU - Malapelle, Umberto
AU - Morelli, Luca
AU - Giovannetti, Elisa
N1 - Funding Information: Benoit Immordino , obtained his PharmD degree from the University of Aix Marseille. During his training at SMARTc Unit, Centre de Recherche en Cancérologie de Marseille, Inserm, Aix Marseille Université , Marseille (France) he worked on nanoliposomes. Current position: assistant researcher at FPS, Pisa, Italy, supported by AIRC. Fields of interest: pancreatic cancer, extracellular vesicles, translational research, pharmacology. Funding Information: Elisa Giovannetti , MD, PhD. Associate Professor, Head of the “Molecular Mechanism of Drug Activity” group, Amsterdam UMC, VU University medical center, Department Laboratory Medical Oncology, Cancer Center Amsterdam, Amsterdam (Netherlands). She is actively involved, as elected chair, in research projects within the “Pharmacology” group of the EORTC (EORTC-PAMM). She successfully requested funding from the Netherlands Organization for Scientific Research (NWO, VENI grant), Marie Sklodowska Curie Actions and European Initiatives (H2020-MSCA-RISE “Alise” and COST “Stratagem”), AIRC (Start-Up and IG grants), CCA Foundation, and Dutch Cancer Society. Dr. Giovannetti is (co-)author of > 300 scientific publications in peer reviewed Journals (Scholar H-index, 58). Funding Information: This research was funded by Rotary Global Grant GG2123321 (to A.C.), CCA Foundation 2018 (The Netherlands), KWF 13598 (The Netherlands) and AIRC IG-24444 (Italy) grant (to E.G). Funding Information: Mjriam Capula , PhD student, obtained her Bachelor degree in Biotechnologies from the University of Bologna. During her training at Amsterdam UMC, and at Fondazione Pisana per la Scienza (FPS), Italy, she was supported by FPS and Associazione Italiana per la Ricerca sul Cancro (AIRC) grants. Fields of interest: pancreatic cancer, biomarkers, microbiome, microRNA, preclinical and translational research. Publisher Copyright: © 2022 Elsevier B.V.
PY - 2022/5/1
Y1 - 2022/5/1
N2 - Attempts to achieve early diagnosis are crucial to improve the outcome of patients with pancreatic ductal adenocarcinoma (PDAC). Here we present a critical evaluation of a recent study unraveling the potential of circulating AXL as a novel blood marker for early detection of PDAC and differential diagnosis from chronic pancreatitis (CP).
AB - Attempts to achieve early diagnosis are crucial to improve the outcome of patients with pancreatic ductal adenocarcinoma (PDAC). Here we present a critical evaluation of a recent study unraveling the potential of circulating AXL as a novel blood marker for early detection of PDAC and differential diagnosis from chronic pancreatitis (CP).
KW - AXL
KW - Diagnosis
KW - Liquid biopsies
KW - Pancreatic cancer
UR - http://www.scopus.com/inward/record.url?scp=85127926774&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.critrevonc.2022.103659
DO - https://doi.org/10.1016/j.critrevonc.2022.103659
M3 - Comment/Letter to the editor
C2 - 35398264
SN - 1040-8428
VL - 173
JO - Critical Reviews in Oncology/Hematology
JF - Critical Reviews in Oncology/Hematology
M1 - 103659
ER -