TY - JOUR
T1 - Design of the ExCersion-VCI study
T2 - The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment
AU - Heart Brain Connection study group
AU - Leeuwis, Anna E.
AU - Hooghiemstra, Astrid M.
AU - Amier, Raquel
AU - Ferro, Doeschka A.
AU - Franken, Leonie
AU - Nijveldt, Robin
AU - Kuijer, Joost P.A.
AU - Bronzwaer, Anne Sophie G.T.
AU - van Lieshout, Johannes J.
AU - Rietberg, Marc B.
AU - Veerbeek, Janne M.
AU - Huijsmans, Rosalie J.
AU - Backx, Frank J.G.
AU - Teunissen, Charlotte E.
AU - Bron, Esther E.
AU - Barkhof, Frederik
AU - Prins, Niels D.
AU - Shahzad, Rahil
AU - Niessen, Wiro J.
AU - de Roos, Albert
AU - van Osch, Matthias J.P.
AU - van Rossum, Albert C.
AU - Biessels, Geert J.
AU - van der Flier, Wiesje M.
PY - 2017/6/1
Y1 - 2017/6/1
N2 - There is evidence for a beneficial effect of aerobic exercise on cognition, but underlying mechanisms are unclear. In this study, we test the hypothesis that aerobic exercise increases cerebral blood flow (CBF) in patients with vascular cognitive impairment (VCI). This study is a multicenter single-blind randomized controlled trial among 80 patients with VCI. Most important inclusion criteria are a diagnosis of VCI with Mini-Mental State Examination ≥22 and Clinical Dementia Rating ≤0.5. Participants are randomized into an aerobic exercise group or a control group. The aerobic exercise program aims to improve cardiorespiratory fitness and takes 14 weeks, with a frequency of three times a week. Participants are provided with a bicycle ergometer at home. The control group receives two information meetings. Primary outcome measure is change in CBF. We expect this study to provide insight into the potential mechanism by which aerobic exercise improves hemodynamic status.
AB - There is evidence for a beneficial effect of aerobic exercise on cognition, but underlying mechanisms are unclear. In this study, we test the hypothesis that aerobic exercise increases cerebral blood flow (CBF) in patients with vascular cognitive impairment (VCI). This study is a multicenter single-blind randomized controlled trial among 80 patients with VCI. Most important inclusion criteria are a diagnosis of VCI with Mini-Mental State Examination ≥22 and Clinical Dementia Rating ≤0.5. Participants are randomized into an aerobic exercise group or a control group. The aerobic exercise program aims to improve cardiorespiratory fitness and takes 14 weeks, with a frequency of three times a week. Participants are provided with a bicycle ergometer at home. The control group receives two information meetings. Primary outcome measure is change in CBF. We expect this study to provide insight into the potential mechanism by which aerobic exercise improves hemodynamic status.
KW - Arterial spin labeling
KW - Cerebral blood flow
KW - Cognition
KW - Exercise
KW - Randomized clinical trial
KW - Vascular cognitive impairment
UR - http://www.scopus.com/inward/record.url?scp=85016005137&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.trci.2017.02.002
DO - https://doi.org/10.1016/j.trci.2017.02.002
M3 - Article
C2 - 29067325
SN - 2352-8737
VL - 3
SP - 157
EP - 165
JO - Alzheimer's and Dementia: Translational Research and Clinical Interventions
JF - Alzheimer's and Dementia: Translational Research and Clinical Interventions
IS - 2
ER -