TY - JOUR
T1 - Desire for children among male survivors of childhood cancer
T2 - A DCCSS LATER study
AU - Claessens, Joyce J. M.
AU - Penson, Adriaan
AU - Bronkhorst, Ewald M.
AU - Kremer, Leontien C. M.
AU - van Dulmen-den Broeder, Eline
AU - van der Heiden-van der Loo, Margriet
AU - Tissing, Wim J. E.
AU - van der Pal, Helena J. H.
AU - Blijlevens, Nicole M. A.
AU - van den Heuvel-Eibrink, Marry M.
AU - Versluys, A. Birgitta
AU - Bresters, Dorine
AU - Ronckers, C. cile M.
AU - Walraven, Iris
AU - Dutch LATER Study Group
AU - Beerendonk, Catharina C. M.
AU - Loonen, Jacqueline J.
N1 - Funding Information: We thank all cancer survivors and siblings participating in the study and the Dutch National Childhood Cancer Association for their contribution to the Dutch Childhood Cancer Survivor Study LATER study. We thank the coordinating central office as well as all physicians, research nurses, and data managers at the seven participating centers. Also, we thank Iridi Stollman for her assistance with the data visualization. This work was supported by the Dutch Cancer Society (grant 10151). Funding Information: We thank all cancer survivors and siblings participating in the study and the Dutch National Childhood Cancer Association for their contribution to the Dutch Childhood Cancer Survivor Study LATER study. We thank the coordinating central office as well as all physicians, research nurses, and data managers at the seven participating centers. Also, we thank Iridi Stollman for her assistance with the data visualization. This work was supported by the Dutch Cancer Society (grant 10151). Publisher Copyright: © 2023 The Authors. Cancer published by Wiley Periodicals LLC on behalf of American Cancer Society.
PY - 2023/5/1
Y1 - 2023/5/1
N2 - Background: Knowledge of the desire for children among childhood cancer survivors (CCSs) is scarce. This study evaluated the desire for children in male CCSs in comparison with male siblings. Methods: A nationwide cohort study was conducted as part of the Dutch Childhood Cancer Survivor Study LATER study: 1317 male CCSs and 407 male sibling controls completed a questionnaire addressing the desire for children. Logistic regression analyses were used to explore the independent association between survivorship status and the desire for children. Furthermore, additional analyses were performed to identify which cancer-related factors were associated with the desire for children in male CCSs. Results: After adjustments for the age at assessment, the percentage of men who had a desire for children was significantly lower among CCSs compared with the siblings (74% vs. 82%; odds ratio [OR], 0.61; 95% CI, 0.46–0.82; p =.001). The association between survivorship status and the desire for children was attenuated after adjustments for marital status, level of education, and employment status (OR, 0.83; 95% CI, 0.61–1.14; p =.250). The percentage of men who had an unfulfilled desire for children remained significantly higher among CCSs compared with the siblings after adjustments for sociodemographic factors (25% vs. 7%; OR, 5.14; 95% CI, 2.48–10.64; p <.001). Conclusions: The majority of male CCSs have a desire for children. The likelihood of having to deal with an unfulfilled desire for children is 5 times higher among CCSs compared with their siblings. This insight is important for understanding the needs and experienced problems of CCSs regarding family planning and fertility issues.
AB - Background: Knowledge of the desire for children among childhood cancer survivors (CCSs) is scarce. This study evaluated the desire for children in male CCSs in comparison with male siblings. Methods: A nationwide cohort study was conducted as part of the Dutch Childhood Cancer Survivor Study LATER study: 1317 male CCSs and 407 male sibling controls completed a questionnaire addressing the desire for children. Logistic regression analyses were used to explore the independent association between survivorship status and the desire for children. Furthermore, additional analyses were performed to identify which cancer-related factors were associated with the desire for children in male CCSs. Results: After adjustments for the age at assessment, the percentage of men who had a desire for children was significantly lower among CCSs compared with the siblings (74% vs. 82%; odds ratio [OR], 0.61; 95% CI, 0.46–0.82; p =.001). The association between survivorship status and the desire for children was attenuated after adjustments for marital status, level of education, and employment status (OR, 0.83; 95% CI, 0.61–1.14; p =.250). The percentage of men who had an unfulfilled desire for children remained significantly higher among CCSs compared with the siblings after adjustments for sociodemographic factors (25% vs. 7%; OR, 5.14; 95% CI, 2.48–10.64; p <.001). Conclusions: The majority of male CCSs have a desire for children. The likelihood of having to deal with an unfulfilled desire for children is 5 times higher among CCSs compared with their siblings. This insight is important for understanding the needs and experienced problems of CCSs regarding family planning and fertility issues.
KW - childhood cancer survivors
KW - desire for children
KW - infertility
KW - male
KW - reproductive behavior
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85150529086&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/36881488
UR - http://www.scopus.com/inward/record.url?scp=85150529086&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/cncr.34685
DO - https://doi.org/10.1002/cncr.34685
M3 - Article
C2 - 36881488
SN - 0008-543X
VL - 129
SP - 1432
EP - 1442
JO - Cancer
JF - Cancer
IS - 9
ER -