TY - JOUR
T1 - Detailed kinetics of EBV-specific CD4+ and CD8+ T cells during primary EBV infection in a kidney transplant patient
AU - Piriou, Erwan R. W. A. N.
AU - van Dort, Karel
AU - Weel, Jan F. L.
AU - Bemelman, Frederike J.
AU - Gamadia, Laila E.
AU - van Oers, Marinus H. J.
AU - van Baarle, Debbie
PY - 2006
Y1 - 2006
N2 - The etiology of infectious mononucleosis is poorly understood and usually detected many weeks after infection. Here, we present a unique case of primary symptomatic EBV infection after kidney transplantation, in whom we analyzed both EBV-specific CD4+ and CD8+ T cells in detail from the moment of infection up to latency. We show that EBV-specific T-cell responses in peripheral blood during primary EBV infection after kidney transplantation peaked early after the appearance of viral load, but well before onset of IM symptoms, suggesting that IM in this case is not caused by high numbers of CD8+ T cells per se but may be caused by lack of homing to lymph nodes or tonsils
AB - The etiology of infectious mononucleosis is poorly understood and usually detected many weeks after infection. Here, we present a unique case of primary symptomatic EBV infection after kidney transplantation, in whom we analyzed both EBV-specific CD4+ and CD8+ T cells in detail from the moment of infection up to latency. We show that EBV-specific T-cell responses in peripheral blood during primary EBV infection after kidney transplantation peaked early after the appearance of viral load, but well before onset of IM symptoms, suggesting that IM in this case is not caused by high numbers of CD8+ T cells per se but may be caused by lack of homing to lymph nodes or tonsils
U2 - https://doi.org/10.1016/j.clim.2005.11.009
DO - https://doi.org/10.1016/j.clim.2005.11.009
M3 - Article
C2 - 16386961
SN - 1521-6616
VL - 119
SP - 16
EP - 20
JO - Clinical immunology (Orlando, Fla.)
JF - Clinical immunology (Orlando, Fla.)
IS - 1
ER -