Detailed kinetics of EBV-specific CD4+ and CD8+ T cells during primary EBV infection in a kidney transplant patient

Erwan R. W. A. N. Piriou, Karel van Dort, Jan F. L. Weel, Frederike J. Bemelman, Laila E. Gamadia, Marinus H. J. van Oers, Debbie van Baarle

Research output: Contribution to journalArticleAcademicpeer-review


The etiology of infectious mononucleosis is poorly understood and usually detected many weeks after infection. Here, we present a unique case of primary symptomatic EBV infection after kidney transplantation, in whom we analyzed both EBV-specific CD4+ and CD8+ T cells in detail from the moment of infection up to latency. We show that EBV-specific T-cell responses in peripheral blood during primary EBV infection after kidney transplantation peaked early after the appearance of viral load, but well before onset of IM symptoms, suggesting that IM in this case is not caused by high numbers of CD8+ T cells per se but may be caused by lack of homing to lymph nodes or tonsils
Original languageEnglish
Pages (from-to)16-20
JournalClinical immunology (Orlando, Fla.)
Issue number1
Publication statusPublished - 2006

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