TY - JOUR
T1 - Determinants of Cross-Sectional and Longitudinal Health-Related Quality of Life in Memory Clinic Patients Without Dementia
AU - Banning, Leonie C. P.
AU - Janssen, Eveline P. C. J.
AU - Hamel, Renske E. G.
AU - de Vugt, Marjolein
AU - Köhler, Sebastian
AU - Wolfs, Claire A. G.
AU - Oosterveld, Saskia M.
AU - Melis, Rene J. F.
AU - Olde Rikkert, Marcel G. M.
AU - Kessels, Roy P. C.
AU - Pijnenburg, Yolande A. L.
AU - Koene, Ted
AU - van der Flier, Wiesje M.
AU - Scheltens, Philip
AU - Visser, Pieter Jelle
AU - Verhey, Frans R. J.
AU - Aalten, Pauline
AU - Ramakers, Inez H. G. B.
PY - 2020/9/1
Y1 - 2020/9/1
N2 - Objective: To identify determinants within 3 different domains (ie, somatic comorbidities, cognitive functioning, and neuropsychiatric symptoms [NPS]) of health-related quality of life (HRQoL) over time in memory clinic patients without dementia. Methods: This longitudinal multicenter cohort study with a 3-year observation period recruited 315 individuals (age: 69.8 ± 8.6, 64.4% males, Mini-Mental State Examination score 26.9 ± 2.6). A multivariable explanatory model was built using linear mixed effects models (forward selection per domain) to select determinants for self-perceived HRQoL over time, as measured by the EuroQoL-5D visual analogue scale (EQ VAS). Results: Mean HRQoL at study entry was 69.4 ± 15.6. The presence of agitation, appetite and eating abnormalities, and eyes/ears/nose (ie, sensory impairment) comorbidities were associated with a change in HRQoL over time. Agitation was most strongly associated with HRQoL over time. Conclusions: The association of somatic comorbidities and NPS in memory clinic patients with course of HRQoL shows that these should receive more awareness, detection, and monitoring by clinicians.
AB - Objective: To identify determinants within 3 different domains (ie, somatic comorbidities, cognitive functioning, and neuropsychiatric symptoms [NPS]) of health-related quality of life (HRQoL) over time in memory clinic patients without dementia. Methods: This longitudinal multicenter cohort study with a 3-year observation period recruited 315 individuals (age: 69.8 ± 8.6, 64.4% males, Mini-Mental State Examination score 26.9 ± 2.6). A multivariable explanatory model was built using linear mixed effects models (forward selection per domain) to select determinants for self-perceived HRQoL over time, as measured by the EuroQoL-5D visual analogue scale (EQ VAS). Results: Mean HRQoL at study entry was 69.4 ± 15.6. The presence of agitation, appetite and eating abnormalities, and eyes/ears/nose (ie, sensory impairment) comorbidities were associated with a change in HRQoL over time. Agitation was most strongly associated with HRQoL over time. Conclusions: The association of somatic comorbidities and NPS in memory clinic patients with course of HRQoL shows that these should receive more awareness, detection, and monitoring by clinicians.
KW - cognitive functioning
KW - health-related quality of life
KW - mild cognitive impairment
KW - neuropsychiatric symptoms
KW - somatic comorbidities
KW - subjective cognitive decline
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85074531611&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/31645191
U2 - https://doi.org/10.1177/0891988719882104
DO - https://doi.org/10.1177/0891988719882104
M3 - Article
C2 - 31645191
SN - 0891-9887
VL - 33
SP - 256
EP - 264
JO - Journal of Geriatric Psychiatry and Neurology
JF - Journal of Geriatric Psychiatry and Neurology
IS - 5
ER -