Determinants of Cross-Sectional and Longitudinal Health-Related Quality of Life in Memory Clinic Patients Without Dementia

Leonie C. P. Banning, Eveline P. C. J. Janssen, Renske E. G. Hamel, Marjolein de Vugt, Sebastian Köhler, Claire A. G. Wolfs, Saskia M. Oosterveld, Rene J. F. Melis, Marcel G. M. Olde Rikkert, Roy P. C. Kessels, Yolande A. L. Pijnenburg, Ted Koene, Wiesje M. van der Flier, Philip Scheltens, Pieter Jelle Visser, Frans R. J. Verhey, Pauline Aalten, Inez H. G. B. Ramakers

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6 Citations (Scopus)


Objective: To identify determinants within 3 different domains (ie, somatic comorbidities, cognitive functioning, and neuropsychiatric symptoms [NPS]) of health-related quality of life (HRQoL) over time in memory clinic patients without dementia. Methods: This longitudinal multicenter cohort study with a 3-year observation period recruited 315 individuals (age: 69.8 ± 8.6, 64.4% males, Mini-Mental State Examination score 26.9 ± 2.6). A multivariable explanatory model was built using linear mixed effects models (forward selection per domain) to select determinants for self-perceived HRQoL over time, as measured by the EuroQoL-5D visual analogue scale (EQ VAS). Results: Mean HRQoL at study entry was 69.4 ± 15.6. The presence of agitation, appetite and eating abnormalities, and eyes/ears/nose (ie, sensory impairment) comorbidities were associated with a change in HRQoL over time. Agitation was most strongly associated with HRQoL over time. Conclusions: The association of somatic comorbidities and NPS in memory clinic patients with course of HRQoL shows that these should receive more awareness, detection, and monitoring by clinicians.
Original languageEnglish
Pages (from-to)256-264
Number of pages9
JournalJournal of geriatric psychiatry and neurology
Issue number5
Early online date1 Jan 2019
Publication statusPublished - 1 Sept 2020


  • cognitive functioning
  • health-related quality of life
  • mild cognitive impairment
  • neuropsychiatric symptoms
  • somatic comorbidities
  • subjective cognitive decline

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