Determination of the allelic and haplotype frequencies of three polymorphisms in the promoter region of the human protein C gene

C. A. Spek, S. R. Poort, R. M. Bertina, P. H. Reitsma

Research output: Contribution to journalComment/Letter to the editorAcademic

25 Citations (Scopus)

Abstract

The frequencies of three polymorphisms in the promoter region of the human protein C gene (C/T at -1654, A/G at -1641 and A/T at -1476) have been determined. All three polymorphisms show allelic frequencies of about 0.60 and 0.40. The determination of the frequencies of the haplotypes of these polymorphisms showed that three of them (CGT, TAA and CAA) account for 88% of the observed haplotypes
Original languageEnglish
Pages (from-to)309-311
JournalBlood coagulation & fibrinolysis
Volume5
Issue number2
DOIs
Publication statusPublished - 1994

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