TY - CHAP
T1 - Development and multiparametric evaluation of experimental atherosclerosis in rabbits
AU - Senders, Max L.
AU - Lobatto, Mark E.
AU - Soler, Raphael
AU - Lairez, Olivier
AU - Pérez-Medina, Carlos
AU - Calcagno, Claudia
AU - Fayad, Zahi A.
AU - Mulder, Willem J. M.
AU - Fay, Francois
PY - 2018
Y1 - 2018
N2 - Several animal models have been developed to study atherosclerosis. Here we present a rabbit atherosclerosis model generated by surgical denudation of the aortic endothelium in combination with a high-fat and cholesterol-enriched diet. This model is characterized by the formation of vascular lesions that exhibit several hallmarks of human atherosclerosis. Due to the rabbit’s relative large size, as compared to rodents, this model is suited for the imaging-guided evaluation of novel therapeutic strategies using clinical scanners. In this chapter, we present an extensive outline of the procedures to induce aortic atherosclerotic lesions in rabbits as well as methods to evaluate the disease, including noninvasive in vivo multiparametric imaging and histopathology.
AB - Several animal models have been developed to study atherosclerosis. Here we present a rabbit atherosclerosis model generated by surgical denudation of the aortic endothelium in combination with a high-fat and cholesterol-enriched diet. This model is characterized by the formation of vascular lesions that exhibit several hallmarks of human atherosclerosis. Due to the rabbit’s relative large size, as compared to rodents, this model is suited for the imaging-guided evaluation of novel therapeutic strategies using clinical scanners. In this chapter, we present an extensive outline of the procedures to induce aortic atherosclerotic lesions in rabbits as well as methods to evaluate the disease, including noninvasive in vivo multiparametric imaging and histopathology.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85050142818&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/29987836
U2 - https://doi.org/10.1007/978-1-4939-8597-5_30
DO - https://doi.org/10.1007/978-1-4939-8597-5_30
M3 - Chapter
C2 - 29987836
VL - 1816
T3 - Methods in Molecular Biology
SP - 385
EP - 400
BT - Methods in Molecular Biology
PB - Humana Press Inc.
ER -