TY - JOUR
T1 - Development of enzymic zonation in liver parenchyma is related to development of acinar architecture
AU - Lamers, W. H.
AU - Gaasbeek Janzen, J. W.
AU - Kortschot, A. T.
AU - Charles, R.
AU - Moorman, A. F.
PY - 1987
Y1 - 1987
N2 - The appearance of the distribution patterns of the NH3-metabolizing enzymes carbamoylphosphate synthetase, glutamate dehydrogenase, and glutamine synthetase in the developing liver of an altricial species (rat) was compared with that in the developing liver of a closely related, precocial species (spiny mouse). The comparison showed that the development of hepatic acinar architecture, rather than perinatal adaptation, is responsible for the development of periportal and pericentral compartments of gene expression. Conditions that confine the expression of specific enzymes to the pericentral compartment of the acinus originate before conditions that confine the expression of (other) specific enzymes to the periportal compartment. However, whether or not the site of gene expression is restricted to specific compartments within the liver acinus, the rate of expression of the gene involved can also be adaptively regulated. Therefore, different factors appear to control the site and the rate of gene expression within one tissue
AB - The appearance of the distribution patterns of the NH3-metabolizing enzymes carbamoylphosphate synthetase, glutamate dehydrogenase, and glutamine synthetase in the developing liver of an altricial species (rat) was compared with that in the developing liver of a closely related, precocial species (spiny mouse). The comparison showed that the development of hepatic acinar architecture, rather than perinatal adaptation, is responsible for the development of periportal and pericentral compartments of gene expression. Conditions that confine the expression of specific enzymes to the pericentral compartment of the acinus originate before conditions that confine the expression of (other) specific enzymes to the periportal compartment. However, whether or not the site of gene expression is restricted to specific compartments within the liver acinus, the rate of expression of the gene involved can also be adaptively regulated. Therefore, different factors appear to control the site and the rate of gene expression within one tissue
U2 - https://doi.org/10.1111/j.1432-0436.1987.tb00173.x
DO - https://doi.org/10.1111/j.1432-0436.1987.tb00173.x
M3 - Article
C2 - 2895721
SN - 0301-4681
VL - 35
SP - 228
EP - 235
JO - Differentiation; research in biological diversity
JF - Differentiation; research in biological diversity
IS - 3
ER -