Development of multidrug-resistance convertors: Sense or nonsense?

Lia Van Zuylen, Kees Nooter, Alex Sparreboom, Jaap Verweij

Research output: Contribution to journalReview articleAcademicpeer-review

93 Citations (Scopus)

Abstract

This review describes the clinical relevance of the two drug transporters P-glycoprotein (Pgp) and multidrug resistance-associated protein (MRP) and the in vitro phenomenon which is referred to as multidrug resistance (MDR). The attempts to try to block these resistance mechanisms are summarized with specific attention for the intentionally designed 'second generation' MDR-convertors. Potential explanations of the limited clinical success rate are given and recommendations for the design of future studies provided.

Original languageEnglish
Pages (from-to)205-220
Number of pages16
JournalInvestigational new drugs
Volume18
Issue number3
DOIs
Publication statusPublished - 1 Jan 2000
Externally publishedYes

Keywords

  • Cancer
  • MDR-convertors
  • MRP
  • Multidrug resistance
  • P-glycoprotein

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