TY - JOUR
T1 - Diabetes mellitus, hypertension and medial temporal lobe atrophy
T2 - The LADIS study
AU - Korf, E. S.C.
AU - Van Straaten, E. C.W.
AU - De Leeuw, F. E.
AU - Van Der Flier, W. M.
AU - Barkhof, F.
AU - Pantoni, L.
AU - Basile, A. M.
AU - Inzitari, D.
AU - Erkinjuntti, T.
AU - Wahlund, L. O.
AU - Rostrup, E.
AU - Schmidt, R.
AU - Fazekas, F.
AU - Scheltens, P.
PY - 2007/2/1
Y1 - 2007/2/1
N2 - Hypothesis: Based on recent findings on the association between vascular risk factors and hippocampal atrophy, we hypothesized that hypertension and diabetes mellitus (DM) are associated with medial temporal lobe atrophy (MTA) in subjects without disability, independent of the severity of white matter hyperintensities. Methods: In the Leukoaraiosis And DISability in the elderly (LADIS) study, we investigated the relationships between DM, hypertension, blood pressure and MTA in 582 subjects, stratified by white matter hyperintensity severity, using multinomial logistic regression. MTA was visually scored for the left and right medial temporal lobe (score 0-4), and meaned. Results: Mean age was 73.5 years (sd 5.1), 54% was female. Of the subjects, 15% had DM, and 70% had a history of hypertension. The likelihood of having MTA score 3 was significantly higher in subjects with DM (OR 2.9; 95% CI: 1.1-7.8) compared with an MTA score of 0 (no atrophy). The odds ratio for MTA score 2 was not significantly increased (OR 1.8; CI: 0.9-4). Systolic and diastolic blood pressure and a history of hypertension were not associated with MTA. There was no interaction between DM and hypertension. Stratification on white matter hyperintensities (WMH) did not alter the associations. Conclusion: Our study strengthens the observation that MTA is associated with DM, independently of the amount of small vessel disease as reflected by WMH.
AB - Hypothesis: Based on recent findings on the association between vascular risk factors and hippocampal atrophy, we hypothesized that hypertension and diabetes mellitus (DM) are associated with medial temporal lobe atrophy (MTA) in subjects without disability, independent of the severity of white matter hyperintensities. Methods: In the Leukoaraiosis And DISability in the elderly (LADIS) study, we investigated the relationships between DM, hypertension, blood pressure and MTA in 582 subjects, stratified by white matter hyperintensity severity, using multinomial logistic regression. MTA was visually scored for the left and right medial temporal lobe (score 0-4), and meaned. Results: Mean age was 73.5 years (sd 5.1), 54% was female. Of the subjects, 15% had DM, and 70% had a history of hypertension. The likelihood of having MTA score 3 was significantly higher in subjects with DM (OR 2.9; 95% CI: 1.1-7.8) compared with an MTA score of 0 (no atrophy). The odds ratio for MTA score 2 was not significantly increased (OR 1.8; CI: 0.9-4). Systolic and diastolic blood pressure and a history of hypertension were not associated with MTA. There was no interaction between DM and hypertension. Stratification on white matter hyperintensities (WMH) did not alter the associations. Conclusion: Our study strengthens the observation that MTA is associated with DM, independently of the amount of small vessel disease as reflected by WMH.
KW - Diabetes mellitus
KW - Hypertension
KW - Medial temporal lobe atrophy
KW - Non-disabled
KW - White matter hyperintensities
UR - http://www.scopus.com/inward/record.url?scp=33846648054&partnerID=8YFLogxK
U2 - https://doi.org/10.1111/j.1464-5491.2007.02049.x
DO - https://doi.org/10.1111/j.1464-5491.2007.02049.x
M3 - Article
C2 - 17257279
SN - 0742-3071
VL - 24
SP - 166
EP - 171
JO - Diabetic medicine
JF - Diabetic medicine
IS - 2
ER -