TY - JOUR
T1 - Diagnosis of myocardial infarction at autopsy: AECVP reappraisal in the light of the current clinical classification
AU - on behalf of the Association for European Cardiovascular Pathology (AECVP)
AU - Michaud, Katarzyna
AU - Basso, Cristina
AU - d’Amati, Giulia
AU - Giordano, Carla
AU - Kholová, Ivana
AU - Preston, Stephen D.
AU - Rizzo, Stefania
AU - Sabatasso, Sara
AU - Sheppard, Mary N.
AU - Vink, Aryan
AU - van der Wal, Allard C.
PY - 2020/2/1
Y1 - 2020/2/1
N2 - Ischemic heart disease is one of the leading causes of morbidity and death worldwide. Consequently, myocardial infarctions are often encountered in clinical and forensic autopsies, and diagnosis can be challenging, especially in the absence of an acute coronary occlusion. Precise histopathological identification and timing of myocardial infarction in humans often remains uncertain while it can be of crucial importance, especially in a forensic setting when third person involvement or medical responsibilities are in question. A proper post-mortem diagnosis requires not only up-to-date knowledge of the ischemic coronary and myocardial pathology, but also a correct interpretation of such findings in relation to the clinical scenario of the deceased. For these reasons, it is important for pathologists to be familiar with the different clinically defined types of myocardial infarction and to discriminate myocardial infarction from other forms of myocardial injury. This article reviews present knowledge and post-mortem diagnostic methods, including post-mortem imaging, to reveal the different types of myocardial injury and the clinical-pathological correlations with currently defined types of myocardial infarction.
AB - Ischemic heart disease is one of the leading causes of morbidity and death worldwide. Consequently, myocardial infarctions are often encountered in clinical and forensic autopsies, and diagnosis can be challenging, especially in the absence of an acute coronary occlusion. Precise histopathological identification and timing of myocardial infarction in humans often remains uncertain while it can be of crucial importance, especially in a forensic setting when third person involvement or medical responsibilities are in question. A proper post-mortem diagnosis requires not only up-to-date knowledge of the ischemic coronary and myocardial pathology, but also a correct interpretation of such findings in relation to the clinical scenario of the deceased. For these reasons, it is important for pathologists to be familiar with the different clinically defined types of myocardial infarction and to discriminate myocardial infarction from other forms of myocardial injury. This article reviews present knowledge and post-mortem diagnostic methods, including post-mortem imaging, to reveal the different types of myocardial injury and the clinical-pathological correlations with currently defined types of myocardial infarction.
UR - http://www.scopus.com/inward/record.url?scp=85073973912&partnerID=8YFLogxK
U2 - https://doi.org/10.1007/s00428-019-02662-1
DO - https://doi.org/10.1007/s00428-019-02662-1
M3 - Review article
C2 - 31522288
SN - 0945-6317
VL - 476
SP - 179
EP - 194
JO - Virchows Archiv
JF - Virchows Archiv
IS - 2
ER -