TY - JOUR
T1 - Diagnostic and Prognostic Value of miRNAs after Coronary Artery Bypass Grafting
T2 - A Review
AU - Błażejowska, Ewelina
AU - Urbanowicz, Tomasz
AU - Gąsecka, Aleksandra
AU - Olasińska-Wiśniewska, Anna
AU - Jaguszewski, Miłosz J.
AU - Targoński, Radosław
AU - Szarpak, Łukasz
AU - Filipiak, Krzysztof J.
AU - Perek, Bartłomiej
AU - Jemielity, Marek
PY - 2021/12/1
Y1 - 2021/12/1
N2 - MiRNAs are noncoding, 21–24 nucleotide-long RNA particles that control over 60% of genes. MiRNAs affect gene expression through binding to the 3’-untranslated region of messenger RNA (mRNA), thus inhibiting mRNA translation or inducing mRNA degradation. MiRNAs have been associated with various cardiovascular diseases, including heart failure, hypertension, left ventricular hypertrophy, or ischemic heart disease. In addition, miRNA expression alters during coronary artery bypass grafting (CABG) surgery, which could be used to predict perioperative outcomes. CABG is an operation in which complex coronary arteries stenosis is treated by bypassing atherosclerotic lesions with venous or arterial grafts. Despite a very low perioperative mortality rate and excellent long-term survival, CABG is associated with postoperative complications, including reperfusion injury, graft failure, atrial fibrillation and perioperative myocardial infarction. So far, no reliable diagnostic and prognostic tools to predict prognosis after CABG have been developed. Changes in the perioperative miRNA expression levels could improve the diagnosis of post-CABG myocardial infarction and atrial fibrillation and could be used to stratify risk after CABG. Herein, we describe the expression changes of different subtypes of miRNAs during CABG and review the diagnostic and prognostic utility of miRNAs in patients undergoing CABG.
AB - MiRNAs are noncoding, 21–24 nucleotide-long RNA particles that control over 60% of genes. MiRNAs affect gene expression through binding to the 3’-untranslated region of messenger RNA (mRNA), thus inhibiting mRNA translation or inducing mRNA degradation. MiRNAs have been associated with various cardiovascular diseases, including heart failure, hypertension, left ventricular hypertrophy, or ischemic heart disease. In addition, miRNA expression alters during coronary artery bypass grafting (CABG) surgery, which could be used to predict perioperative outcomes. CABG is an operation in which complex coronary arteries stenosis is treated by bypassing atherosclerotic lesions with venous or arterial grafts. Despite a very low perioperative mortality rate and excellent long-term survival, CABG is associated with postoperative complications, including reperfusion injury, graft failure, atrial fibrillation and perioperative myocardial infarction. So far, no reliable diagnostic and prognostic tools to predict prognosis after CABG have been developed. Changes in the perioperative miRNA expression levels could improve the diagnosis of post-CABG myocardial infarction and atrial fibrillation and could be used to stratify risk after CABG. Herein, we describe the expression changes of different subtypes of miRNAs during CABG and review the diagnostic and prognostic utility of miRNAs in patients undergoing CABG.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85122937280&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/34943265
U2 - https://doi.org/10.3390/biology10121350
DO - https://doi.org/10.3390/biology10121350
M3 - Article
C2 - 34943265
SN - 2079-7737
VL - 10
JO - Biology
JF - Biology
IS - 12
M1 - 1350
ER -