TY - JOUR
T1 - Diagnostics in Waldenström’s macroglobulinemia
T2 - a consensus statement of the European Consortium for Waldenström’s Macroglobulinemia
AU - Dogliotti, Irene
AU - Jiménez, Cristina
AU - Varettoni, Marzia
AU - Talaulikar, Dipti
AU - Bagratuni, Tina
AU - Ferrante, Martina
AU - Pérez, José
AU - Drandi, Daniela
AU - Puig, Noemí
AU - Gilestro, Milena
AU - García-Álvarez, María
AU - Owen, Roger
AU - Jurczak, Wojciech
AU - Tedeschi, Alessandra
AU - Leblond, Veronique
AU - Kastritis, Efstathios
AU - Kersten, Marie José
AU - D’Sa, Shirley
AU - Kaščák, Michal
AU - Willenbacher, Wolfgang
AU - Roccaro, Aldo M.
AU - Poulain, Stephanie
AU - Morel, Pierre
AU - Kyriakou, Charalampia
AU - Fend, Falko
AU - Vos, Josephine M. I.
AU - Dimopoulos, Meletios A.
AU - Buske, Christian
AU - Ferrero, Simone
AU - García-Sanz, Ramón
N1 - Funding Information: This study was supported by the European Consortium for Waldenström’s Macroglobulinemia. Publisher Copyright: © 2022, The Author(s).
PY - 2023/2
Y1 - 2023/2
N2 - The diagnosis of Waldenström’s macroglobulinemia (WM), an IgM-associated lymphoplasmacytic lymphoma, can be challenging due to the different forms of disease presentation. Furthermore, in recent years, WM has witnessed remarkable progress on the diagnostic front, as well as a deeper understanding of the disease biology, which has affected clinical practice. This, together with the increasing variety of tools and techniques available, makes it necessary to have a practical guidance for clinicians to perform the initial evaluation of patients with WM. In this paper, we present the consensus recommendations and laboratory requirements for the diagnosis of WM developed by the European Consortium of Waldenström’s Macroglobulinemia (ECWM), for both clinical practice as well as the research/academical setting. We provide the procedures for multiparametric flow cytometry, fluorescence in situ hybridization and molecular tests, and with this offer guidance for a standardized diagnostic work-up and methodological workflow of patients with IgM monoclonal gammopathy of uncertain significance, asymptomatic and symptomatic WM.
AB - The diagnosis of Waldenström’s macroglobulinemia (WM), an IgM-associated lymphoplasmacytic lymphoma, can be challenging due to the different forms of disease presentation. Furthermore, in recent years, WM has witnessed remarkable progress on the diagnostic front, as well as a deeper understanding of the disease biology, which has affected clinical practice. This, together with the increasing variety of tools and techniques available, makes it necessary to have a practical guidance for clinicians to perform the initial evaluation of patients with WM. In this paper, we present the consensus recommendations and laboratory requirements for the diagnosis of WM developed by the European Consortium of Waldenström’s Macroglobulinemia (ECWM), for both clinical practice as well as the research/academical setting. We provide the procedures for multiparametric flow cytometry, fluorescence in situ hybridization and molecular tests, and with this offer guidance for a standardized diagnostic work-up and methodological workflow of patients with IgM monoclonal gammopathy of uncertain significance, asymptomatic and symptomatic WM.
UR - http://www.scopus.com/inward/record.url?scp=85142541121&partnerID=8YFLogxK
U2 - https://doi.org/10.1038/s41375-022-01762-3
DO - https://doi.org/10.1038/s41375-022-01762-3
M3 - Article
C2 - 36435884
SN - 0887-6924
VL - 37
SP - 388
EP - 395
JO - Leukemia
JF - Leukemia
IS - 2
ER -