Diaphragm Muscle Fiber Weakness and Ubiquitin-Proteasome Activation in Critically Ill Patients

P.E. Hooijman; A. Beishuizen; C.C. Witt; M.C. de Waard; A.R.J. Girbes; A.M.E. Spoelstra-de Man; H.W. Niessen; E. Manders; H.W.H. van Hees; C.E. van den Brom; V. Silderhuis; M.W. Lawlor; S. Labeit; G.J.M. Stienen; K.J. Hartemink; M.A. Paul; L.M.A. Heunks; C.A.C. Ottenheijm

doi:https://doi.org/10.1164/rccm.201412-2214OC

Diaphragm Muscle Fiber Weakness and Ubiquitin-Proteasome Activation in Critically Ill Patients

P.E. Hooijman, A. Beishuizen, C.C. Witt, M.C. de Waard, A.R.J. Girbes, A.M.E. Spoelstra-de Man, H.W. Niessen, E. Manders, H.W.H. van Hees, C.E. van den Brom, V. Silderhuis, M.W. Lawlor, S. Labeit, G.J.M. Stienen, K.J. Hartemink, M.A. Paul, L.M.A. Heunks, C.A.C. Ottenheijm

Research output: Contribution to journal › Article › Academic › peer-review

141 Citations (Scopus)

Abstract

RATIONALE: The clinical significance of diaphragm weakness in critically ill patients is evident: it prolongs ventilator dependency, and increases morbidity and duration of hospital stay. To date, the nature of diaphragm weakness and its underlying pathophysiologic mechanisms are poorly understood.

Original language	English
Pages (from-to)	1126-1138
Number of pages	13
Journal	American journal of respiratory and critical care medicine
Volume	191
Issue number	10
DOIs	https://doi.org/10.1164/rccm.201412-2214OC
Publication status	Published - 15 May 2015

Keywords

Adult
Aged
Aged, 80 and over
Animals
Biopsy
Blotting, Western
Case-Control Studies
Critical Illness
Diaphragm
Disease Models, Animal
Female
Humans
Journal Article
Length of Stay
Male
Mice
Mice, Knockout
Middle Aged
Muscle Fibers, Skeletal
Muscle Proteins
Muscle Weakness
Muscular Atrophy
Netherlands
Proteasome Endopeptidase Complex
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Respiration, Artificial
Tripartite Motif Proteins
Ubiquitin
Ubiquitin-Protein Ligases
Young Adult

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

https://doi.org/10.1164/rccm.201412-2214OC

Cite this

Hooijman, P. E., Beishuizen, A., Witt, C. C., de Waard, M. C., Girbes, A. R. J., Spoelstra-de Man, A. M. E., Niessen, H. W., Manders, E., van Hees, H. W. H., van den Brom, C. E., Silderhuis, V., Lawlor, M. W., Labeit, S., Stienen, G. J. M., Hartemink, K. J., Paul, M. A., Heunks, L. M. A., & Ottenheijm, C. A. C. (2015). Diaphragm Muscle Fiber Weakness and Ubiquitin-Proteasome Activation in Critically Ill Patients. American journal of respiratory and critical care medicine, 191(10), 1126-1138. https://doi.org/10.1164/rccm.201412-2214OC

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abstract = "RATIONALE: The clinical significance of diaphragm weakness in critically ill patients is evident: it prolongs ventilator dependency, and increases morbidity and duration of hospital stay. To date, the nature of diaphragm weakness and its underlying pathophysiologic mechanisms are poorly understood.",

keywords = "Adult, Aged, Aged, 80 and over, Animals, Biopsy, Blotting, Western, Case-Control Studies, Critical Illness, Diaphragm, Disease Models, Animal, Female, Humans, Journal Article, Length of Stay, Male, Mice, Mice, Knockout, Middle Aged, Muscle Fibers, Skeletal, Muscle Proteins, Muscle Weakness, Muscular Atrophy, Netherlands, Proteasome Endopeptidase Complex, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Respiration, Artificial, Tripartite Motif Proteins, Ubiquitin, Ubiquitin-Protein Ligases, Young Adult",

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year = "2015",

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doi = "https://doi.org/10.1164/rccm.201412-2214OC",

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Hooijman, PE, Beishuizen, A, Witt, CC, de Waard, MC, Girbes, ARJ , Spoelstra-de Man, AME , Niessen, HW , Manders, E, van Hees, HWH, van den Brom, CE, Silderhuis, V, Lawlor, MW, Labeit, S, Stienen, GJM, Hartemink, KJ, Paul, MA, Heunks, LMA & Ottenheijm, CAC 2015, 'Diaphragm Muscle Fiber Weakness and Ubiquitin-Proteasome Activation in Critically Ill Patients', American journal of respiratory and critical care medicine, vol. 191, no. 10, pp. 1126-1138. https://doi.org/10.1164/rccm.201412-2214OC

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AU - Hooijman, P.E.

AU - Beishuizen, A.

AU - Witt, C.C.

AU - de Waard, M.C.

AU - Girbes, A.R.J.

AU - Spoelstra-de Man, A.M.E.

AU - Niessen, H.W.

AU - Manders, E.

AU - van Hees, H.W.H.

AU - van den Brom, C.E.

AU - Silderhuis, V.

AU - Lawlor, M.W.

AU - Labeit, S.

AU - Stienen, G.J.M.

AU - Hartemink, K.J.

AU - Paul, M.A.

AU - Heunks, L.M.A.

AU - Ottenheijm, C.A.C.

PY - 2015/5/15

Y1 - 2015/5/15

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KW - Aged, 80 and over

KW - Animals

KW - Biopsy

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KW - Case-Control Studies

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KW - Disease Models, Animal

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KW - Proteasome Endopeptidase Complex

KW - Research Support, N.I.H., Extramural

KW - Research Support, Non-U.S. Gov't

KW - Respiration, Artificial

KW - Tripartite Motif Proteins

KW - Ubiquitin

KW - Ubiquitin-Protein Ligases

KW - Young Adult

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DO - https://doi.org/10.1164/rccm.201412-2214OC

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SN - 1073-449X

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