TY - JOUR
T1 - Diet-induced changes in the Lean Brain: Hypercaloric high-fat-high-sugar snacking decreases serotonin transporters in the human hypothalamic region
AU - Koopman, Karin Eva
AU - Booij, Jan
AU - Fliers, Eric
AU - Serlie, Mireille Johanna
AU - la Fleur, Susanne Eva
PY - 2013
Y1 - 2013
N2 - It is evident that there is a relationship between the brain's serotonin system and obesity. Although it is clear that drugs affecting The serotonin system regulate appetite and food intake, it is unclear whether changes in The serotonin system are cause or consequence of obesity. To determine whether obesogenic eating habits result in reduced serotonin transporter (SERT)-binding in the human hypothalamic region, we included 25 lean, male subjects who followed a 6-week-hypercaloric diet, which were high-fat-high-sugar (HFHS) or high-sugar (HS) with increased meal size or-frequency (=snacking pattern). We measured SERT-binding in the hypothalamic region with SPELT. All hypercaloric diets significantly increased body weight by 3-3.5%. Although There were no differences in total calories consumed between the diets, only a hypercaloric HFHS-snacking diet decreased SERT-binding significantly by 30%. We here show for the first time in humans that snacking may change the serotonergic system increasing the risk to develop obesity. (C) 2013 The Authors. Published by Elsevier GmbH. All rights reserved
AB - It is evident that there is a relationship between the brain's serotonin system and obesity. Although it is clear that drugs affecting The serotonin system regulate appetite and food intake, it is unclear whether changes in The serotonin system are cause or consequence of obesity. To determine whether obesogenic eating habits result in reduced serotonin transporter (SERT)-binding in the human hypothalamic region, we included 25 lean, male subjects who followed a 6-week-hypercaloric diet, which were high-fat-high-sugar (HFHS) or high-sugar (HS) with increased meal size or-frequency (=snacking pattern). We measured SERT-binding in the hypothalamic region with SPELT. All hypercaloric diets significantly increased body weight by 3-3.5%. Although There were no differences in total calories consumed between the diets, only a hypercaloric HFHS-snacking diet decreased SERT-binding significantly by 30%. We here show for the first time in humans that snacking may change the serotonergic system increasing the risk to develop obesity. (C) 2013 The Authors. Published by Elsevier GmbH. All rights reserved
U2 - https://doi.org/10.1016/j.molmet.2013.07.006
DO - https://doi.org/10.1016/j.molmet.2013.07.006
M3 - Article
C2 - 24327957
SN - 2212-8778
VL - 2
SP - 417
EP - 422
JO - Molecular metabolism
JF - Molecular metabolism
IS - 4
ER -