Dietary intake of carotenoids and risk of type 2 diabetes

I. Sluijs, E. Cadier, J. W.J. Beulens, D. L. van der A, A. M.W. Spijkerman, Y. T. van der Schouw

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156 Citations (Scopus)


Background and aims: Carotenoids may reduce diabetes risk, due to their antioxidant properties. However, the association between dietary carotenoids intake and type 2 diabetes risk is still unclear. Therefore, the objective of this study was to examine whether higher dietary carotenoid intakes associate with reduced type 2 diabetes risk. Methods and results: Data from 37,846 participants of the European Prospective Investigation into Cancer and Nutrition- Netherlands study were analyzed. Dietary intakes of β-carotene, α-carotene, β-cryptoxanthin, lycopene, lutein & zeaxanthin and the sum of these carotenoids were assessed using a validated food frequency questionnaire. Incident type 2 diabetes was mainly self-reported, and verified against general practitioner information. Mean ±SD total carotenoid intake was 10± 4 mg/day. During a mean ±SD follow-up of 10 ± 2years, 915 incident cases of type 2 diabetes were ascertained. After adjustment for age, sex, diabetes risk factors, dietary intake, waist circumference and BMI, higher β-carotene intakes associated inversely with diabetes risk [Hazard Ratio quartile 4 versus quartile 1 (HRQ4): 0.78 (95%CI:0.64,0.95), P-linear trend 0.01]. For α-carotene, a borderline significant reduced risk was observed, with a HRQ4 of 0.85 (95%CI:0.70,1.03), and P-linear trend 0.05. β-cryptoxanthin, lycopene, lutein & zeaxanthin, and the sum of all carotenoids did not associate with diabetes risk. Conclusions: This study shows that diets high in β-carotene and α-carotene are associated with reduced type 2 diabetes in generally healthy men and women.

Original languageEnglish
Pages (from-to)376-381
Number of pages6
JournalNutrition, Metabolism and Cardiovascular Diseases
Issue number4
Publication statusPublished - 1 Jan 2015


  • Carotenoids
  • Cohort study
  • Diet
  • Type 2 diabetes
  • α-carotene
  • β-carotene

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