Dietary patterns are related to cognitive functioning in elderly enriched with individuals at increased risk for Alzheimer’s disease

L. M.P. Wesselman; D. Melo van Lent; A. Schröder; O. van de Rest; O. Peters; F. Menne; M. Fuentes; J. Priller; E. J. Spruth; S. Altenstein; A. Schneider; K. Fließbach; S. Roeske; S. Wolfsgruber; L. Kleineidam; A. Spottke; V. Pross; J. Wiltfang; R. Vukovich; A. K. Schild; E. Düzel; C. D. Metzger; W. Glanz; K. Buerger; D. Janowitz; R. Perneczky; M. Tatò; S. Teipel; I. Kilimann; C. Laske; M. Buchmann; A. Ramirez; S. A.M. Sikkes; F. Jessen; W. M. van der Flier; M. Wagner

doi:https://doi.org/10.1007/s00394-020-02257-6

Dietary patterns are related to cognitive functioning in elderly enriched with individuals at increased risk for Alzheimer’s disease

L. M.P. Wesselman, D. Melo van Lent, A. Schröder, O. van de Rest, O. Peters, F. Menne, M. Fuentes, J. Priller, E. J. Spruth, S. Altenstein, A. Schneider, K. Fließbach, S. Roeske, S. Wolfsgruber, L. Kleineidam, A. Spottke, V. Pross, J. Wiltfang, R. Vukovich, A. K. SchildE. Düzel, C. D. Metzger, W. Glanz, K. Buerger, D. Janowitz, R. Perneczky, M. Tatò, S. Teipel, I. Kilimann, C. Laske, M. Buchmann, A. Ramirez, S. A.M. Sikkes, F. Jessen, W. M. van der Flier, M. Wagner

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Abstract

Purpose: To investigate cross-sectional associations between dietary patterns and cognitive functioning in elderly free of dementia. Methods: Data of 389 participants from the German DELCODE study (52% female, 69 ± 6 years, mean Mini Mental State Score 29 ± 1) were included. The sample was enriched with elderly at increased risk for Alzheimer’s disease (AD) by including participants with subjective cognitive decline, mild cognitive impairment (MCI) and siblings of AD patients. Mediterranean and MIND diets were derived from 148 Food Frequency Questionnaire items, and data-driven patterns by principal component analysis (PCA) of 39 food groups. Associations between dietary patterns and five cognitive domain scores were analyzed with linear regression analyses adjusted for demographics (model 1), and additionally for energy intake, BMI, other lifestyle variables and APOe4-status (model 2). For PCA-derived dietary components, final model 3 included all other dietary components. Results: In fully adjusted models, adherence to Mediterranean and MIND diet was associated with better memory. The ‘alcoholic beverages’ PCA component was positively associated with most cognitive domains. Exclusion of MCI subjects (n = 60) revealed that Mediterranean and MIND diet were also related to language functions; associations with the alcoholic beverages component were attenuated, but most remained significant. Conclusion: In line with data from elderly population samples, Mediterranean and MIND diet and some data-derived dietary patterns were related to memory and language function. Longitudinal data are needed to draw conclusions on the putative effect of nutrition on the rate of cognitive decline, and on the potential of dietary interventions in groups at increased risk for AD.

Original language	English
Pages (from-to)	849-860
Number of pages	12
Journal	European Journal of Nutrition
Volume	60
Issue number	2
DOIs	https://doi.org/10.1007/s00394-020-02257-6
Publication status	Published - 1 Mar 2021

Keywords

Cognition
Dementia
Dietary patterns
MIND diet
Mediterranean diet

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Wesselman, L. M. P., van Lent, D. M., Schröder, A., van de Rest, O., Peters, O., Menne, F., Fuentes, M., Priller, J., Spruth, E. J., Altenstein, S., Schneider, A., Fließbach, K., Roeske, S., Wolfsgruber, S., Kleineidam, L., Spottke, A., Pross, V., Wiltfang, J., Vukovich, R., ... Wagner, M. (2021). Dietary patterns are related to cognitive functioning in elderly enriched with individuals at increased risk for Alzheimer’s disease. European Journal of Nutrition, 60(2), 849-860. https://doi.org/10.1007/s00394-020-02257-6

@article{5ddf3a90d8b743d892b91e9c90313a05,

title = "Dietary patterns are related to cognitive functioning in elderly enriched with individuals at increased risk for Alzheimer{\textquoteright}s disease",

abstract = "Purpose: To investigate cross-sectional associations between dietary patterns and cognitive functioning in elderly free of dementia. Methods: Data of 389 participants from the German DELCODE study (52% female, 69 ± 6 years, mean Mini Mental State Score 29 ± 1) were included. The sample was enriched with elderly at increased risk for Alzheimer{\textquoteright}s disease (AD) by including participants with subjective cognitive decline, mild cognitive impairment (MCI) and siblings of AD patients. Mediterranean and MIND diets were derived from 148 Food Frequency Questionnaire items, and data-driven patterns by principal component analysis (PCA) of 39 food groups. Associations between dietary patterns and five cognitive domain scores were analyzed with linear regression analyses adjusted for demographics (model 1), and additionally for energy intake, BMI, other lifestyle variables and APOe4-status (model 2). For PCA-derived dietary components, final model 3 included all other dietary components. Results: In fully adjusted models, adherence to Mediterranean and MIND diet was associated with better memory. The {\textquoteleft}alcoholic beverages{\textquoteright} PCA component was positively associated with most cognitive domains. Exclusion of MCI subjects (n = 60) revealed that Mediterranean and MIND diet were also related to language functions; associations with the alcoholic beverages component were attenuated, but most remained significant. Conclusion: In line with data from elderly population samples, Mediterranean and MIND diet and some data-derived dietary patterns were related to memory and language function. Longitudinal data are needed to draw conclusions on the putative effect of nutrition on the rate of cognitive decline, and on the potential of dietary interventions in groups at increased risk for AD.",

keywords = "Cognition, Dementia, Dietary patterns, MIND diet, Mediterranean diet",

author = "Wesselman, {L. M.P.} and {van Lent}, {D. Melo} and A. Schr{\"o}der and {van de Rest}, O. and O. Peters and F. Menne and M. Fuentes and J. Priller and Spruth, {E. J.} and S. Altenstein and A. Schneider and K. Flie{\ss}bach and S. Roeske and S. Wolfsgruber and L. Kleineidam and A. Spottke and V. Pross and J. Wiltfang and R. Vukovich and Schild, {A. K.} and E. D{\"u}zel and Metzger, {C. D.} and W. Glanz and K. Buerger and D. Janowitz and R. Perneczky and M. Tat{\`o} and S. Teipel and I. Kilimann and C. Laske and M. Buchmann and A. Ramirez and Sikkes, {S. A.M.} and F. Jessen and {van der Flier}, {W. M.} and M. Wagner",

note = "Funding Information: This project has been funded by the DZNE and by the Diet Body Brain research cluster funded by the German Federal Ministry of Education and Research (BMBF; grant 01EA1809C). LW received an International Research Grant from the Alzheimer Forschung Initiative e.V. SS is a recipient of a research grant from the EU Joint Programme-Neurodegenerative Disease Research (JPND_PS_FP-689–019; ZonMw Grant no. 733051043) and a research grant from Stichting Equilibrio. WvdF is recipient of a grant from NWO-FCB (NUDAD; project number 057–14-004). Acknowledgements Funding Information: We would like to thank all the participants for their contribution to this study. We kindly thank Ulrich Harttig, Sabine Grams and Ellen Kohlsdorf from the DIfE in Potsdam, Germany, for hosting the EPIC-FFQ data base and for their support with the data of this study. Publisher Copyright: {\textcopyright} 2020, The Author(s).",

year = "2021",

month = mar,

day = "1",

doi = "https://doi.org/10.1007/s00394-020-02257-6",

language = "English",

volume = "60",

pages = "849--860",

journal = "European Journal of Nutrition",

issn = "1436-6207",

publisher = "D. Steinkopff-Verlag",

number = "2",

}

Wesselman, LMP, van Lent, DM, Schröder, A, van de Rest, O, Peters, O, Menne, F, Fuentes, M, Priller, J, Spruth, EJ, Altenstein, S, Schneider, A, Fließbach, K, Roeske, S, Wolfsgruber, S, Kleineidam, L, Spottke, A, Pross, V, Wiltfang, J, Vukovich, R, Schild, AK, Düzel, E, Metzger, CD, Glanz, W, Buerger, K, Janowitz, D, Perneczky, R, Tatò, M, Teipel, S, Kilimann, I, Laske, C, Buchmann, M, Ramirez, A, Sikkes, SAM, Jessen, F, van der Flier, WM & Wagner, M 2021, 'Dietary patterns are related to cognitive functioning in elderly enriched with individuals at increased risk for Alzheimer’s disease', European Journal of Nutrition, vol. 60, no. 2, pp. 849-860. https://doi.org/10.1007/s00394-020-02257-6

TY - JOUR

T1 - Dietary patterns are related to cognitive functioning in elderly enriched with individuals at increased risk for Alzheimer’s disease

AU - Wesselman, L. M.P.

AU - van Lent, D. Melo

AU - Schröder, A.

AU - van de Rest, O.

AU - Peters, O.

AU - Menne, F.

AU - Fuentes, M.

AU - Priller, J.

AU - Spruth, E. J.

AU - Altenstein, S.

AU - Schneider, A.

AU - Fließbach, K.

AU - Roeske, S.

AU - Wolfsgruber, S.

AU - Kleineidam, L.

AU - Spottke, A.

AU - Pross, V.

AU - Wiltfang, J.

AU - Vukovich, R.

AU - Schild, A. K.

AU - Düzel, E.

AU - Metzger, C. D.

AU - Glanz, W.

AU - Buerger, K.

AU - Janowitz, D.

AU - Perneczky, R.

AU - Tatò, M.

AU - Teipel, S.

AU - Kilimann, I.

AU - Laske, C.

AU - Buchmann, M.

AU - Ramirez, A.

AU - Sikkes, S. A.M.

AU - Jessen, F.

AU - van der Flier, W. M.

AU - Wagner, M.

N1 - Funding Information: This project has been funded by the DZNE and by the Diet Body Brain research cluster funded by the German Federal Ministry of Education and Research (BMBF; grant 01EA1809C). LW received an International Research Grant from the Alzheimer Forschung Initiative e.V. SS is a recipient of a research grant from the EU Joint Programme-Neurodegenerative Disease Research (JPND_PS_FP-689–019; ZonMw Grant no. 733051043) and a research grant from Stichting Equilibrio. WvdF is recipient of a grant from NWO-FCB (NUDAD; project number 057–14-004). Acknowledgements Funding Information: We would like to thank all the participants for their contribution to this study. We kindly thank Ulrich Harttig, Sabine Grams and Ellen Kohlsdorf from the DIfE in Potsdam, Germany, for hosting the EPIC-FFQ data base and for their support with the data of this study. Publisher Copyright: © 2020, The Author(s).

PY - 2021/3/1

Y1 - 2021/3/1

N2 - Purpose: To investigate cross-sectional associations between dietary patterns and cognitive functioning in elderly free of dementia. Methods: Data of 389 participants from the German DELCODE study (52% female, 69 ± 6 years, mean Mini Mental State Score 29 ± 1) were included. The sample was enriched with elderly at increased risk for Alzheimer’s disease (AD) by including participants with subjective cognitive decline, mild cognitive impairment (MCI) and siblings of AD patients. Mediterranean and MIND diets were derived from 148 Food Frequency Questionnaire items, and data-driven patterns by principal component analysis (PCA) of 39 food groups. Associations between dietary patterns and five cognitive domain scores were analyzed with linear regression analyses adjusted for demographics (model 1), and additionally for energy intake, BMI, other lifestyle variables and APOe4-status (model 2). For PCA-derived dietary components, final model 3 included all other dietary components. Results: In fully adjusted models, adherence to Mediterranean and MIND diet was associated with better memory. The ‘alcoholic beverages’ PCA component was positively associated with most cognitive domains. Exclusion of MCI subjects (n = 60) revealed that Mediterranean and MIND diet were also related to language functions; associations with the alcoholic beverages component were attenuated, but most remained significant. Conclusion: In line with data from elderly population samples, Mediterranean and MIND diet and some data-derived dietary patterns were related to memory and language function. Longitudinal data are needed to draw conclusions on the putative effect of nutrition on the rate of cognitive decline, and on the potential of dietary interventions in groups at increased risk for AD.

AB - Purpose: To investigate cross-sectional associations between dietary patterns and cognitive functioning in elderly free of dementia. Methods: Data of 389 participants from the German DELCODE study (52% female, 69 ± 6 years, mean Mini Mental State Score 29 ± 1) were included. The sample was enriched with elderly at increased risk for Alzheimer’s disease (AD) by including participants with subjective cognitive decline, mild cognitive impairment (MCI) and siblings of AD patients. Mediterranean and MIND diets were derived from 148 Food Frequency Questionnaire items, and data-driven patterns by principal component analysis (PCA) of 39 food groups. Associations between dietary patterns and five cognitive domain scores were analyzed with linear regression analyses adjusted for demographics (model 1), and additionally for energy intake, BMI, other lifestyle variables and APOe4-status (model 2). For PCA-derived dietary components, final model 3 included all other dietary components. Results: In fully adjusted models, adherence to Mediterranean and MIND diet was associated with better memory. The ‘alcoholic beverages’ PCA component was positively associated with most cognitive domains. Exclusion of MCI subjects (n = 60) revealed that Mediterranean and MIND diet were also related to language functions; associations with the alcoholic beverages component were attenuated, but most remained significant. Conclusion: In line with data from elderly population samples, Mediterranean and MIND diet and some data-derived dietary patterns were related to memory and language function. Longitudinal data are needed to draw conclusions on the putative effect of nutrition on the rate of cognitive decline, and on the potential of dietary interventions in groups at increased risk for AD.

KW - Cognition

KW - Dementia

KW - Dietary patterns

KW - MIND diet

KW - Mediterranean diet

UR - http://www.scopus.com/inward/record.url?scp=85085757084&partnerID=8YFLogxK

U2 - https://doi.org/10.1007/s00394-020-02257-6

DO - https://doi.org/10.1007/s00394-020-02257-6

M3 - Article

C2 - 32472387

SN - 1436-6207

VL - 60

SP - 849

EP - 860

JO - European Journal of Nutrition

JF - European Journal of Nutrition

IS - 2

ER -

Dietary patterns are related to cognitive functioning in elderly enriched with individuals at increased risk for Alzheimer’s disease

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Keywords

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