Differences between hereditary and sporadic ovarian cancer

R P Zweemer; R H Verheijen; F H Menko; J J Gille; P J van Diest; J W Coebergh; P A Shaw; I J Jacobs; P Kenemans

Differences between hereditary and sporadic ovarian cancer

R P Zweemer, R H Verheijen, F H Menko, J J Gille, P J van Diest, J W Coebergh, P A Shaw, I J Jacobs, P Kenemans

Research output: Contribution to journal › Article › Academic › peer-review

7 Citations (Scopus)

Abstract

Approximately 5% of ovarian cancer cases can be attributed to an autosomal dominant inheritance factor. The majority of these cases are due to germline mutations in the BRCA1 or BRCA2 tumoursupressor genes. Patients with hereditary disease do not exhibit pathognomonic features that would allow distinction from non-hereditary (sporadic) cases of ovarian cancer. Our studies are aimed at identifying clinical, histopathological as well as molecular genetic differences between hereditary and sporadic ovarian cancer. Clinical studies of the ovarian cancer cases in 31 families revealed differences regarding age at onset and stage as well as in survival compared with cancer registry controls. The molecular studies of hereditary ovarian cancer are still underway and some preliminary data is discussed.

Original language	English
Pages (from-to)	151-3
Number of pages	3
Journal	European Journal of Obstetrics and Gynecology and Reproductive Biology
Volume	82
Issue number	2
Publication status	Published - Feb 1999

Keywords

Age Factors
BRCA2 Protein
Female
Genes, BRCA1/genetics
Genes, p53/genetics
Humans
Mutation
Neoplasm Proteins/genetics
Neoplasm Staging
Ovarian Neoplasms/epidemiology
Registries
Survival Rate
Transcription Factors/genetics

Cite this

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title = "Differences between hereditary and sporadic ovarian cancer",

abstract = "Approximately 5% of ovarian cancer cases can be attributed to an autosomal dominant inheritance factor. The majority of these cases are due to germline mutations in the BRCA1 or BRCA2 tumoursupressor genes. Patients with hereditary disease do not exhibit pathognomonic features that would allow distinction from non-hereditary (sporadic) cases of ovarian cancer. Our studies are aimed at identifying clinical, histopathological as well as molecular genetic differences between hereditary and sporadic ovarian cancer. Clinical studies of the ovarian cancer cases in 31 families revealed differences regarding age at onset and stage as well as in survival compared with cancer registry controls. The molecular studies of hereditary ovarian cancer are still underway and some preliminary data is discussed.",

keywords = "Age Factors, BRCA2 Protein, Female, Genes, BRCA1/genetics, Genes, p53/genetics, Humans, Mutation, Neoplasm Proteins/genetics, Neoplasm Staging, Ovarian Neoplasms/epidemiology, Registries, Survival Rate, Transcription Factors/genetics",

author = "Zweemer, {R P} and Verheijen, {R H} and Menko, {F H} and Gille, {J J} and {van Diest}, {P J} and Coebergh, {J W} and Shaw, {P A} and Jacobs, {I J} and P Kenemans",

year = "1999",

month = feb,

language = "English",

volume = "82",

pages = "151--3",

journal = "European journal of obstetrics, gynecology, and reproductive biology",

issn = "0301-2115",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - Differences between hereditary and sporadic ovarian cancer

AU - Zweemer, R P

AU - Verheijen, R H

AU - Menko, F H

AU - Gille, J J

AU - van Diest, P J

AU - Coebergh, J W

AU - Shaw, P A

AU - Jacobs, I J

AU - Kenemans, P

PY - 1999/2

Y1 - 1999/2

N2 - Approximately 5% of ovarian cancer cases can be attributed to an autosomal dominant inheritance factor. The majority of these cases are due to germline mutations in the BRCA1 or BRCA2 tumoursupressor genes. Patients with hereditary disease do not exhibit pathognomonic features that would allow distinction from non-hereditary (sporadic) cases of ovarian cancer. Our studies are aimed at identifying clinical, histopathological as well as molecular genetic differences between hereditary and sporadic ovarian cancer. Clinical studies of the ovarian cancer cases in 31 families revealed differences regarding age at onset and stage as well as in survival compared with cancer registry controls. The molecular studies of hereditary ovarian cancer are still underway and some preliminary data is discussed.

AB - Approximately 5% of ovarian cancer cases can be attributed to an autosomal dominant inheritance factor. The majority of these cases are due to germline mutations in the BRCA1 or BRCA2 tumoursupressor genes. Patients with hereditary disease do not exhibit pathognomonic features that would allow distinction from non-hereditary (sporadic) cases of ovarian cancer. Our studies are aimed at identifying clinical, histopathological as well as molecular genetic differences between hereditary and sporadic ovarian cancer. Clinical studies of the ovarian cancer cases in 31 families revealed differences regarding age at onset and stage as well as in survival compared with cancer registry controls. The molecular studies of hereditary ovarian cancer are still underway and some preliminary data is discussed.

KW - Age Factors

KW - BRCA2 Protein

KW - Female

KW - Genes, BRCA1/genetics

KW - Genes, p53/genetics

KW - Humans

KW - Mutation

KW - Neoplasm Proteins/genetics

KW - Neoplasm Staging

KW - Ovarian Neoplasms/epidemiology

KW - Registries

KW - Survival Rate

KW - Transcription Factors/genetics

M3 - Article

C2 - 10206407

SN - 0301-2115

VL - 82

SP - 151

EP - 153

JO - European journal of obstetrics, gynecology, and reproductive biology

JF - European journal of obstetrics, gynecology, and reproductive biology

IS - 2

ER -