TY - JOUR
T1 - Differences in the prevalence of intermediate hyperglycaemia and the associated incidence of type 2 diabetes mellitus by ethnicity
T2 - The HELIUS study
AU - van Olden, C. C.
AU - Muilwijk, M.
AU - Stronks, K.
AU - van den Born, B. J.
AU - Moll van Charante, E. P.
AU - Nicolaou, M.
AU - Zwinderma, A. H.
AU - Nieuwdorp, M.
AU - Groen, A. K.
AU - van Valkengoed, I. G. M.
AU - Nicolau, M.
N1 - Funding Information: C.C. van Olden was supported by a NNF GUTMMM, Denmark grant 2016. M.N. is supported by a personal ZONMW VICI grant 2020 [09150182010020]. The Academic Medical Center (AMC) of Amsterdam and the Public Health Service of Amsterdam (GGD Amsterdam) provided core financial support for HELIUS. The HELIUS study is also funded by research grants of the Dutch Heart Foundation (Hartstichting; grant no. 2010T084 ), the Netherlands Organization for Health Research and Development (ZonMw; grant no. 200500003 ), the European Integration Fund (EIF; grant no. 2013EIF013 ) and the European Union (Seventh Framework Programme, FP-7; grant no. 278901 ). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2022
PY - 2022/5/1
Y1 - 2022/5/1
N2 - Aims: We aimed to describe differences in the prevalence of intermediate hyperglycaemia (IH) between six ethnic groups. Moreover, to investigate differences in the association of the classifications of IH with the incidence of T2DM between ethnic groups. Methods: We included 3759 Dutch, 2826 African Surinamese, 1646 Ghanaian, 2571 Turkish, 2691 Moroccan and 1970 South Asian Surinamese origin participants of the HELIUS study. IH was measured by fasting plasma glucose (FPG) and HbA1c. We calculated age-, BMI and physical-activity-adjusted prevalence of IH by sex, and calculated age and sex-adjusted hazard ratios (HR)for the association between IH and T2DM in each ethnic group. Results: The prevalence of IH was higher among ethnic minority groups (68.6–41.7%) than the Dutch majority (34.9%). The prevalence of IH categories varied across subgroups. Combined increased FPG and HbA1c was most prevalent in South-Asian Surinamese men (27.6%, 95 %CI: 24.5–30.9%), and in Dutch women (4.2%, 95 %CI: 3.4–5.1%). The HRs for T2DM for each IH-classification did not differ significantly between ethnic groups. HRs were highest for the combined classification, e.g., HR = 8.1, 95 %CI: 2.5–26.6 in the Dutch. Conclusion: We found a higher prevalence of IH in ethnic minority versus majority groups, but did not find evidence for a differential association of IH with incident T2DM.
AB - Aims: We aimed to describe differences in the prevalence of intermediate hyperglycaemia (IH) between six ethnic groups. Moreover, to investigate differences in the association of the classifications of IH with the incidence of T2DM between ethnic groups. Methods: We included 3759 Dutch, 2826 African Surinamese, 1646 Ghanaian, 2571 Turkish, 2691 Moroccan and 1970 South Asian Surinamese origin participants of the HELIUS study. IH was measured by fasting plasma glucose (FPG) and HbA1c. We calculated age-, BMI and physical-activity-adjusted prevalence of IH by sex, and calculated age and sex-adjusted hazard ratios (HR)for the association between IH and T2DM in each ethnic group. Results: The prevalence of IH was higher among ethnic minority groups (68.6–41.7%) than the Dutch majority (34.9%). The prevalence of IH categories varied across subgroups. Combined increased FPG and HbA1c was most prevalent in South-Asian Surinamese men (27.6%, 95 %CI: 24.5–30.9%), and in Dutch women (4.2%, 95 %CI: 3.4–5.1%). The HRs for T2DM for each IH-classification did not differ significantly between ethnic groups. HRs were highest for the combined classification, e.g., HR = 8.1, 95 %CI: 2.5–26.6 in the Dutch. Conclusion: We found a higher prevalence of IH in ethnic minority versus majority groups, but did not find evidence for a differential association of IH with incident T2DM.
KW - Diabetes Mellitus type 2
KW - Ethnicity
KW - HELIUS-study
KW - Intermediate hyperglycaemia
UR - http://www.scopus.com/inward/record.url?scp=85127512487&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.diabres.2022.109859
DO - https://doi.org/10.1016/j.diabres.2022.109859
M3 - Article
C2 - 35367312
SN - 0168-8227
VL - 187
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
M1 - 109859
ER -