TY - JOUR
T1 - Different patterns of cortical gray matter loss over time in behavioral variant frontotemporal dementia and Alzheimer's disease
AU - Möller, Christiane
AU - Hafkemeijer, Anne
AU - Pijnenburg, Yolande A. L.
AU - Rombouts, Serge A. R. B.
AU - van der Grond, Jeroen
AU - Dopper, Elise
AU - van Swieten, John
AU - Versteeg, Adriaan
AU - Steenwijk, Martijn D.
AU - Barkhof, Frederik
AU - Scheltens, Philip
AU - Vrenken, Hugo
AU - van der Flier, Wiesje M.
PY - 2016/2
Y1 - 2016/2
N2 - We examined patterns of cortical thickness loss and cognitive decline over time in 19 patients with Alzheimer's disease (AD), 10 with behavioral variant frontotemporal dementia (bvFTD), and 34 controls with a mean interval of 2.1 ± 0.4 years. We measured vertexwise and regional cortical thickness changes of 6 lobar regions of interest between groups with the longitudinal FreeSurfer pipeline. Compared with controls, AD and bvFTD had a steeper rate of cognitive decline and showed faster cortical thinning per year. Decrease of thickness over time was highest in AD and generalized throughout the whole brain, most pronounced posteriorly, whereas bvFTD patients had a more selective loss in frontal cortex and in anterior parts of the temporal lobes. In a direct comparison, AD patients showed faster cortical thinning in the insula, temporal, and parietal regions, whereas bvFTD patients only showed faster cortical thinning in the orbitofrontal gyrus. Decline of cognitive performances was in line with cortical thinning and deteriorated the most in AD patients.
AB - We examined patterns of cortical thickness loss and cognitive decline over time in 19 patients with Alzheimer's disease (AD), 10 with behavioral variant frontotemporal dementia (bvFTD), and 34 controls with a mean interval of 2.1 ± 0.4 years. We measured vertexwise and regional cortical thickness changes of 6 lobar regions of interest between groups with the longitudinal FreeSurfer pipeline. Compared with controls, AD and bvFTD had a steeper rate of cognitive decline and showed faster cortical thinning per year. Decrease of thickness over time was highest in AD and generalized throughout the whole brain, most pronounced posteriorly, whereas bvFTD patients had a more selective loss in frontal cortex and in anterior parts of the temporal lobes. In a direct comparison, AD patients showed faster cortical thinning in the insula, temporal, and parietal regions, whereas bvFTD patients only showed faster cortical thinning in the orbitofrontal gyrus. Decline of cognitive performances was in line with cortical thinning and deteriorated the most in AD patients.
KW - Alzheimer's disease
KW - Behavioral variant frontotemporal dementia
KW - Cognition
KW - Gray matter thickness
KW - Longitudinal
U2 - https://doi.org/10.1016/j.neurobiolaging.2015.10.020
DO - https://doi.org/10.1016/j.neurobiolaging.2015.10.020
M3 - Article
C2 - 26827640
SN - 0197-4580
VL - 38
SP - 21
EP - 31
JO - Neurobiology of aging
JF - Neurobiology of aging
ER -