TY - JOUR
T1 - Differential Impact of Risk Factors for Women and Men on the Risk of Major Depressive Disorder
AU - Stegenga, Bauke T.
AU - King, Michael
AU - Grobbee, Diederick E.
AU - Torres-González, Francisco
AU - Švab, Igor
AU - Maaroos, Heidi-Ingrid
AU - Xavier, Miguel
AU - Saldivia, Sandra
AU - Bottomley, Christian
AU - Nazareth, Irwin
AU - Geerlings, Mirjam I.
PY - 2012/6
Y1 - 2012/6
N2 - Purpose: Our aim is to examine which risk factors have a greater impact in women than in men on the risk of major depressive disorder (MDD) and whether factors differ between a possible recurrent MDD and a first onset of MDD. Methods: Prospective cohort study of general practice attendees in seven countries, who were followed up at 6 and 12 months (predictD). Absolute risk differences (interaction contrast) across sex for onset of DSM-IV MDD after 6 or 12 months of follow-up were estimated for 35 risk factors from 7101 participants without MDD at baseline. Results: A total of 599 participants (80% female) had an onset of MDD at 6 or 12 months. Most risk factors had a greater impact in women than in men on the risk of MDD and were not restricted to a specific class of risk factors. After we stratified for a history of depressive symptoms, we found that the impact of risk factors across sex was generally stronger on possible recurrent MDD than on a first onset of MDD. Conclusions: Our findings may partly account for the observed difference in incidence of MDD between men and women. © 2012 Elsevier Inc.
AB - Purpose: Our aim is to examine which risk factors have a greater impact in women than in men on the risk of major depressive disorder (MDD) and whether factors differ between a possible recurrent MDD and a first onset of MDD. Methods: Prospective cohort study of general practice attendees in seven countries, who were followed up at 6 and 12 months (predictD). Absolute risk differences (interaction contrast) across sex for onset of DSM-IV MDD after 6 or 12 months of follow-up were estimated for 35 risk factors from 7101 participants without MDD at baseline. Results: A total of 599 participants (80% female) had an onset of MDD at 6 or 12 months. Most risk factors had a greater impact in women than in men on the risk of MDD and were not restricted to a specific class of risk factors. After we stratified for a history of depressive symptoms, we found that the impact of risk factors across sex was generally stronger on possible recurrent MDD than on a first onset of MDD. Conclusions: Our findings may partly account for the observed difference in incidence of MDD between men and women. © 2012 Elsevier Inc.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84861409645&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/22625996
U2 - https://doi.org/10.1016/j.annepidem.2012.04.011
DO - https://doi.org/10.1016/j.annepidem.2012.04.011
M3 - Article
C2 - 22625996
SN - 1047-2797
VL - 22
SP - 388
EP - 396
JO - Annals of epidemiology
JF - Annals of epidemiology
IS - 6
ER -