@article{632bd59eefd74376b0f49fca7cbb763d,
title = "Disruption in structural-functional network repertoire and time-resolved subcortical fronto-temporoparietal connectivity in disorders of consciousness",
abstract = "Understanding recovery of consciousness and elucidating its underlying mechanism is believed to be crucial in the field of basic neuroscience and medicine. Ideas such as the global neuronal workspace (GNW) and the mesocircuit theory hypothesize that failure of recovery in conscious states coincide with loss of connectivity between subcortical and frontoparietal areas, a loss of the repertoire of functional networks states and metastable brain activation. We adopted a time-resolved functional connectivity framework to explore these ideas and assessed the repertoire of functional network states as a potential marker of consciousness and its potential ability to tell apart patients in the unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS). In addition, the prediction of these functional network states by underlying hidden spatial patterns in the anatomical network, that is so-called eigenmodes, was supplemented as potential markers. By analysing time-resolved functional connectivity from functional MRI data, we demonstrated a reduction of metastability and functional network repertoire in UWS compared to MCS patients. This was expressed in terms of diminished dwell times and loss of nonstationarity in the default mode network and subcortical fronto-temporoparietal network in UWS compared to MCS patients. We further demonstrated that these findings co-occurred with a loss of dynamic interplay between structural eigenmodes and emerging time-resolved functional connectivity in UWS. These results are, amongst others, in support of the GNW theory and the mesocircuit hypothesis, underpinning the role of time-resolved thalamo-cortical connections and metastability in the recovery of consciousness.",
keywords = "computational biology, disorders of consciousness, dynamic connectivity, eigenmodes, fMRI, global neuronal workspace, human, mesocircuit, systems biology",
author = "Rajanikant Panda and Aurore Thibaut and Ane Lopez-Gonzalez and Anira Escrichs and Bahri, {Mohamed Ali} and Arjan Hillebrand and Gustavo Deco and Steven Laureys and Olivia Gosseries and Jitka Annen and Prejaas Tewarie",
note = "Funding Information: Funder Grant reference number Author Horizon 2020 Framework Programme 945539 Gustavo Deco Steven LaureysHorizon 2020 Framework Programme 785907 Steven LaureysHorizon 2020 Framework Programme 778234 Steven LaureysThe Belgian National Funds for Scientific Research (F.R.S-FNRS) Rajanikant Panda Aurore Thibaut Olivia Gosseries Steven LaureysEuropean Space Agency Steven LaureysSwiss National Science Foundation Sinergia (170873) Ane Lopez-GonzalezBelgian Federal Science Policy Office PRODEX Programme Steven LaureysFondazione Europea di Ricerca Biomedica Steven LaureysBial Foundation Olivia Gosseries Steven LaureysThe fund Generet Steven LaureysKing Baudouin Foundation Steven LaureysLeon Fredericq Foundation Steven Laureys Aurore Thibaut Olivia GosseriesThe DoCMA Project EU-H2020-MSCA–RISE– 778234 Aurore ThibautFLAG-ERA JTC PCI2018-092891 Gustavo DecoThe Spanish Ministry Project PSI2016-75688-P (AEI/FEDER) Gustavo DecoThe Catalan Research Group Support 2017 SGR 1 Gustavo DecoMinisterio de Ciencia, Innovaci{\'o}n y Universidades Gustavo DecoAgencia Estatal de Investigaci{\'o}n Gustavo DecoEuropean Regional Development Fund Gustavo DecoFonds De La Recherche Scientifique-FNRS PDR project T.0134.21. Funding Information: Swiss National Science Foundation Funding Information: National Natural Science Foundation of China Funding Information: The Belgian National Funds for Scientific Research (F.R.S-FNRS) Publisher Copyright: {\textcopyright} Panda et al.",
year = "2022",
month = aug,
day = "2",
doi = "https://doi.org/10.7554/eLife.77462",
language = "English",
volume = "11",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications Limited",
}