Distinct effects of tafazzin deletion in differentiated and undifferentiated mitochondria

Devrim Acehan; Zaza Khuchua; Riekelt H. Houtkooper; Ashim Malhotra; Johanna Kaufman; Frédéric M. Vaz; Mindong Ren; Howard A. Rockman; David L. Stokes; Michael Schlame

doi:https://doi.org/10.1016/j.mito.2008.12.001

Distinct effects of tafazzin deletion in differentiated and undifferentiated mitochondria

Devrim Acehan, Zaza Khuchua, Riekelt H. Houtkooper, Ashim Malhotra, Johanna Kaufman, Frédéric M. Vaz, Mindong Ren, Howard A. Rockman, David L. Stokes, Michael Schlame

Amsterdam Gastroenterology Endocrinology Metabolism (AMC)

Research output: Contribution to journal › Article › Academic › peer-review

61 Citations (Scopus)

Abstract

Tafazzin is a conserved mitochondrial protein that is required to maintain normal content and composition of cardiolipin. We used electron tomography to investigate the effect of tafazzin deletion on mitochondrial structure and found that cellular differentiation plays a crucial role in the manifestation of abnormalities. This conclusion was reached by comparing differentiated cardiomyocytes with embryonic stem cells from mouse and by comparing different tissues from Drosophila melanogaster. The data suggest that tafazzin deficiency affects cardiolipin in all mitochondria, but significant alterations of the ultrastructure, such as remodeling and aggregation of inner membranes, will only occur after specific differentiation

Original language	English
Pages (from-to)	86-95
Journal	Mitochondrion
Volume	9
Issue number	2
DOIs	https://doi.org/10.1016/j.mito.2008.12.001
Publication status	Published - 2009

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https://doi.org/10.1016/j.mito.2008.12.001

Cite this

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title = "Distinct effects of tafazzin deletion in differentiated and undifferentiated mitochondria",

abstract = "Tafazzin is a conserved mitochondrial protein that is required to maintain normal content and composition of cardiolipin. We used electron tomography to investigate the effect of tafazzin deletion on mitochondrial structure and found that cellular differentiation plays a crucial role in the manifestation of abnormalities. This conclusion was reached by comparing differentiated cardiomyocytes with embryonic stem cells from mouse and by comparing different tissues from Drosophila melanogaster. The data suggest that tafazzin deficiency affects cardiolipin in all mitochondria, but significant alterations of the ultrastructure, such as remodeling and aggregation of inner membranes, will only occur after specific differentiation",

author = "Devrim Acehan and Zaza Khuchua and Houtkooper, {Riekelt H.} and Ashim Malhotra and Johanna Kaufman and Vaz, {Fr{\'e}d{\'e}ric M.} and Mindong Ren and Rockman, {Howard A.} and Stokes, {David L.} and Michael Schlame",

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T1 - Distinct effects of tafazzin deletion in differentiated and undifferentiated mitochondria

AU - Acehan, Devrim

AU - Khuchua, Zaza

AU - Houtkooper, Riekelt H.

AU - Malhotra, Ashim

AU - Kaufman, Johanna

AU - Vaz, Frédéric M.

AU - Ren, Mindong

AU - Rockman, Howard A.

AU - Stokes, David L.

AU - Schlame, Michael

PY - 2009

Y1 - 2009

N2 - Tafazzin is a conserved mitochondrial protein that is required to maintain normal content and composition of cardiolipin. We used electron tomography to investigate the effect of tafazzin deletion on mitochondrial structure and found that cellular differentiation plays a crucial role in the manifestation of abnormalities. This conclusion was reached by comparing differentiated cardiomyocytes with embryonic stem cells from mouse and by comparing different tissues from Drosophila melanogaster. The data suggest that tafazzin deficiency affects cardiolipin in all mitochondria, but significant alterations of the ultrastructure, such as remodeling and aggregation of inner membranes, will only occur after specific differentiation

AB - Tafazzin is a conserved mitochondrial protein that is required to maintain normal content and composition of cardiolipin. We used electron tomography to investigate the effect of tafazzin deletion on mitochondrial structure and found that cellular differentiation plays a crucial role in the manifestation of abnormalities. This conclusion was reached by comparing differentiated cardiomyocytes with embryonic stem cells from mouse and by comparing different tissues from Drosophila melanogaster. The data suggest that tafazzin deficiency affects cardiolipin in all mitochondria, but significant alterations of the ultrastructure, such as remodeling and aggregation of inner membranes, will only occur after specific differentiation

U2 - https://doi.org/10.1016/j.mito.2008.12.001

DO - https://doi.org/10.1016/j.mito.2008.12.001

M3 - Article

C2 - 19114128

SN - 1567-7249

VL - 9

SP - 86

EP - 95

JO - Mitochondrion

JF - Mitochondrion

IS - 2

ER -