Distinct functions of DC-SIGN and its homologues L-SIGN (DC-SIGNR) and mSIGNR1 in pathogen recognition and immune regulation

Estella A Koppel; Klaas P J M van Gisbergen; Teunis B H Geijtenbeek; Yvette van Kooyk

doi:https://doi.org/10.1111/j.1462-5822.2004.00480.x

Distinct functions of DC-SIGN and its homologues L-SIGN (DC-SIGNR) and mSIGNR1 in pathogen recognition and immune regulation

Estella A Koppel, Klaas P J M van Gisbergen, Teunis B H Geijtenbeek, Yvette van Kooyk

Research output: Contribution to journal › Review article › Academic › peer-review

112 Citations (Scopus)

Abstract

Antigen presenting cells express C-type lectins that are involved in pathogen capture, processing and antigen presentation to induce immune responses against these pathogens. However, it is becoming clear that pathogens have evolved to subvert the function of some C-type lectins to escape immune surveillance. An important C-type lectin family is represented by DC-SIGN and its homologues in human and mouse. Here we discuss the structure in relation to the pathogen binding specificity of the SIGN receptors and the function of these receptors in mouse and humans.

Original language	English
Pages (from-to)	157-165
Number of pages	9
Journal	Cellular microbiology
Volume	7
Issue number	2
DOIs	https://doi.org/10.1111/j.1462-5822.2004.00480.x https://doi.org/10.1111/J.1462-5822.2004.00480.x
Publication status	Published - Feb 2005

Keywords

Animals
Antigen-Presenting Cells/immunology
Antigens, CD/biosynthesis
Cell Adhesion Molecules/biosynthesis
Humans
Lectins, C-Type/biosynthesis
Mice
Receptors, Cell Surface/biosynthesis

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Cite this

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title = "Distinct functions of DC-SIGN and its homologues L-SIGN (DC-SIGNR) and mSIGNR1 in pathogen recognition and immune regulation",

abstract = "Antigen presenting cells express C-type lectins that are involved in pathogen capture, processing and antigen presentation to induce immune responses against these pathogens. However, it is becoming clear that pathogens have evolved to subvert the function of some C-type lectins to escape immune surveillance. An important C-type lectin family is represented by DC-SIGN and its homologues in human and mouse. Here we discuss the structure in relation to the pathogen binding specificity of the SIGN receptors and the function of these receptors in mouse and humans.",

keywords = "Animals, Antigen-Presenting Cells/immunology, Antigens, CD/biosynthesis, Cell Adhesion Molecules/biosynthesis, Humans, Lectins, C-Type/biosynthesis, Mice, Receptors, Cell Surface/biosynthesis",

author = "Koppel, {Estella A} and {van Gisbergen}, {Klaas P J M} and Geijtenbeek, {Teunis B H} and {van Kooyk}, Yvette",

year = "2005",

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doi = "https://doi.org/10.1111/j.1462-5822.2004.00480.x",

language = "English",

volume = "7",

pages = "157--165",

journal = "Cellular microbiology",

issn = "1462-5814",

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T1 - Distinct functions of DC-SIGN and its homologues L-SIGN (DC-SIGNR) and mSIGNR1 in pathogen recognition and immune regulation

AU - Koppel, Estella A

AU - van Gisbergen, Klaas P J M

AU - Geijtenbeek, Teunis B H

AU - van Kooyk, Yvette

PY - 2005/2

Y1 - 2005/2

N2 - Antigen presenting cells express C-type lectins that are involved in pathogen capture, processing and antigen presentation to induce immune responses against these pathogens. However, it is becoming clear that pathogens have evolved to subvert the function of some C-type lectins to escape immune surveillance. An important C-type lectin family is represented by DC-SIGN and its homologues in human and mouse. Here we discuss the structure in relation to the pathogen binding specificity of the SIGN receptors and the function of these receptors in mouse and humans.

AB - Antigen presenting cells express C-type lectins that are involved in pathogen capture, processing and antigen presentation to induce immune responses against these pathogens. However, it is becoming clear that pathogens have evolved to subvert the function of some C-type lectins to escape immune surveillance. An important C-type lectin family is represented by DC-SIGN and its homologues in human and mouse. Here we discuss the structure in relation to the pathogen binding specificity of the SIGN receptors and the function of these receptors in mouse and humans.

KW - Animals

KW - Antigen-Presenting Cells/immunology

KW - Antigens, CD/biosynthesis

KW - Cell Adhesion Molecules/biosynthesis

KW - Humans

KW - Lectins, C-Type/biosynthesis

KW - Mice

KW - Receptors, Cell Surface/biosynthesis

U2 - https://doi.org/10.1111/j.1462-5822.2004.00480.x

DO - https://doi.org/10.1111/j.1462-5822.2004.00480.x

M3 - Review article

C2 - 15659060

SN - 1462-5814

VL - 7

SP - 157

EP - 165

JO - Cellular microbiology

JF - Cellular microbiology

IS - 2

ER -