Distinct functions of DC-SIGN and its homologues L-SIGN (DC-SIGNR) and mSIGNR1 in pathogen recognition and immune regulation

Estella A Koppel, Klaas P J M van Gisbergen, Teunis B H Geijtenbeek, Yvette van Kooyk

Research output: Contribution to journalReview articleAcademicpeer-review

112 Citations (Scopus)


Antigen presenting cells express C-type lectins that are involved in pathogen capture, processing and antigen presentation to induce immune responses against these pathogens. However, it is becoming clear that pathogens have evolved to subvert the function of some C-type lectins to escape immune surveillance. An important C-type lectin family is represented by DC-SIGN and its homologues in human and mouse. Here we discuss the structure in relation to the pathogen binding specificity of the SIGN receptors and the function of these receptors in mouse and humans.

Original languageEnglish
Pages (from-to)157-165
Number of pages9
JournalCellular microbiology
Issue number2
Publication statusPublished - Feb 2005


  • Animals
  • Antigen-Presenting Cells/immunology
  • Antigens, CD/biosynthesis
  • Cell Adhesion Molecules/biosynthesis
  • Humans
  • Lectins, C-Type/biosynthesis
  • Mice
  • Receptors, Cell Surface/biosynthesis

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