Distinct roles for DC-SIGN+-dendritic cells and Langerhans cells in HIV-1 transmission

Lot de Witte; Alexey Nabatov; Teunis B. H. Geijtenbeek

doi:https://doi.org/10.1016/j.molmed.2007.11.001

Distinct roles for DC-SIGN+-dendritic cells and Langerhans cells in HIV-1 transmission

Lot de Witte, Alexey Nabatov, Teunis B. H. Geijtenbeek

Research output: Contribution to journal › Review article › Academic › peer-review

99 Citations (Scopus)

Abstract

Dendritic cells (DCs) are thought to mediate HIV-1 transmission but it is becoming evident that different DC subsets at the sites of infection have distinct roles. In the genital tissues, two different DC subsets are present: the Langerhans cells (LCs) and the DC-SIGN(+)-DCs. Although DC-SIGN(+)-DCs mediate HIV-1 transmission, recent data demonstrate that LCs prevent HIV-1 transmission by clearing invading HIV-1 particles. However, this protective function of LCs is dependent on the function of the C-type lectin Langerin: blocking Langerin function by high virus concentrations enables HIV-1 transmission by LCs. Here, we will discuss the molecular mechanisms involved in HIV-1 transmission and viral clearance. A better understanding of these processes is crucial to understand and develop strategies to combat transmission

Original language	English
Pages (from-to)	12-19
Journal	Trends in molecular medicine
Volume	14
Issue number	1
DOIs	https://doi.org/10.1016/j.molmed.2007.11.001
Publication status	Published - 2008

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https://doi.org/10.1016/j.molmed.2007.11.001

Cite this

@article{e81b996372f24b61b4ddf856fc677b94,

title = "Distinct roles for DC-SIGN+-dendritic cells and Langerhans cells in HIV-1 transmission",

abstract = "Dendritic cells (DCs) are thought to mediate HIV-1 transmission but it is becoming evident that different DC subsets at the sites of infection have distinct roles. In the genital tissues, two different DC subsets are present: the Langerhans cells (LCs) and the DC-SIGN(+)-DCs. Although DC-SIGN(+)-DCs mediate HIV-1 transmission, recent data demonstrate that LCs prevent HIV-1 transmission by clearing invading HIV-1 particles. However, this protective function of LCs is dependent on the function of the C-type lectin Langerin: blocking Langerin function by high virus concentrations enables HIV-1 transmission by LCs. Here, we will discuss the molecular mechanisms involved in HIV-1 transmission and viral clearance. A better understanding of these processes is crucial to understand and develop strategies to combat transmission",

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T1 - Distinct roles for DC-SIGN+-dendritic cells and Langerhans cells in HIV-1 transmission

AU - de Witte, Lot

AU - Nabatov, Alexey

AU - Geijtenbeek, Teunis B. H.

PY - 2008

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N2 - Dendritic cells (DCs) are thought to mediate HIV-1 transmission but it is becoming evident that different DC subsets at the sites of infection have distinct roles. In the genital tissues, two different DC subsets are present: the Langerhans cells (LCs) and the DC-SIGN(+)-DCs. Although DC-SIGN(+)-DCs mediate HIV-1 transmission, recent data demonstrate that LCs prevent HIV-1 transmission by clearing invading HIV-1 particles. However, this protective function of LCs is dependent on the function of the C-type lectin Langerin: blocking Langerin function by high virus concentrations enables HIV-1 transmission by LCs. Here, we will discuss the molecular mechanisms involved in HIV-1 transmission and viral clearance. A better understanding of these processes is crucial to understand and develop strategies to combat transmission

AB - Dendritic cells (DCs) are thought to mediate HIV-1 transmission but it is becoming evident that different DC subsets at the sites of infection have distinct roles. In the genital tissues, two different DC subsets are present: the Langerhans cells (LCs) and the DC-SIGN(+)-DCs. Although DC-SIGN(+)-DCs mediate HIV-1 transmission, recent data demonstrate that LCs prevent HIV-1 transmission by clearing invading HIV-1 particles. However, this protective function of LCs is dependent on the function of the C-type lectin Langerin: blocking Langerin function by high virus concentrations enables HIV-1 transmission by LCs. Here, we will discuss the molecular mechanisms involved in HIV-1 transmission and viral clearance. A better understanding of these processes is crucial to understand and develop strategies to combat transmission

U2 - https://doi.org/10.1016/j.molmed.2007.11.001

DO - https://doi.org/10.1016/j.molmed.2007.11.001

M3 - Review article

C2 - 18055263

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