TY - JOUR
T1 - Divergent SARS-CoV-2-specific T- and B-cell responses in severe but not mild COVID-19 patients
AU - Oja, Anna E.
AU - Saris, Anno
AU - Ghandour, Cherien A.
AU - Kragten, Natasja A. M.
AU - Hogema, Boris M.
AU - Nossent, Esther J.
AU - Heunks, Leo M. A.
AU - Cuvalay, Susan
AU - Slot, Ed
AU - Linty, Federica
AU - Swaneveld, Francis H.
AU - Vrielink, Hans
AU - Vidarsson, Gestur
AU - Rispens, Theo
AU - van der Schoot, Ellen
AU - van Lier, René A. W.
AU - ten Brinke, Anja
AU - Hombrink, Pleun
N1 - This article is protected by copyright. All rights reserved.
PY - 2020/12
Y1 - 2020/12
N2 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the current coronavirus disease 2019 (COVID-19) pandemic. Understanding the immune response that provides specific immunity but may also lead to immunopathology is crucial for the design of potential preventive and therapeutic strategies. Here, we characterized and quantified SARS-CoV-2-specific immune responses in patients with different clinical courses. Compared to individuals with a mild clinical presentation, CD4+ T-cell responses were qualitatively impaired in critically ill patients. Strikingly, however, in these patients the specific IgG antibody response was remarkably strong. Furthermore, in these critically ill patients, a massive influx of circulating T cells into the lungs was observed, overwhelming the local T-cell compartment, and indicative of vascular leakage. The observed disparate T- and B-cell responses could be indicative of a deregulated immune response in critically ill COVID-19 patients.
AB - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the current coronavirus disease 2019 (COVID-19) pandemic. Understanding the immune response that provides specific immunity but may also lead to immunopathology is crucial for the design of potential preventive and therapeutic strategies. Here, we characterized and quantified SARS-CoV-2-specific immune responses in patients with different clinical courses. Compared to individuals with a mild clinical presentation, CD4+ T-cell responses were qualitatively impaired in critically ill patients. Strikingly, however, in these patients the specific IgG antibody response was remarkably strong. Furthermore, in these critically ill patients, a massive influx of circulating T cells into the lungs was observed, overwhelming the local T-cell compartment, and indicative of vascular leakage. The observed disparate T- and B-cell responses could be indicative of a deregulated immune response in critically ill COVID-19 patients.
KW - CD4 T cells
KW - COVID-19
KW - IgG
KW - SARS-CoV-2
KW - antibody response
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85096705485&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/33073359
UR - http://www.scopus.com/inward/record.url?scp=85096705485&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/eji.202048908
DO - https://doi.org/10.1002/eji.202048908
M3 - Article
C2 - 33073359
SN - 0014-2980
VL - 50
SP - 1998
EP - 2012
JO - European journal of immunology
JF - European journal of immunology
IS - 12
ER -