@article{73480d6cfdd24803b9e021fe8cdc74d4,
title = "DNA methylation as the link between migration and the major noncommunicable diseases: The RODAM study",
abstract = "Aim: We assessed epigenome-wide DNA methylation (DNAm) differences between migrant and non-migrant Ghanaians. Materials & methods: We used the Illumina Infinium{\textregistered} HumanMethylation450 BeadChip to profile DNAm of 712 Ghanaians in whole blood. We used linear models to detect differentially methylated positions (DMPs) associated with migration. We performed multiple post hoc analyses to validate our findings. Results: We identified 13 DMPs associated with migration (delta-beta values: 0.2-4.5%). Seven DMPs in CPLX2, EIF4E3, MEF2D, TLX3, ST8SIA1, ANG and CHRM3 were independent of extrinsic genomic influences in public databases. Two DMPs in NLRC5 were associated with duration of stay in Europe among migrants. All DMPs were biologically linked to migration-related factors. Conclusion: Our findings provide the first insights into DNAm differences between migrants and non-migrants.",
keywords = "DNA methylation, RODAM study, migrants, noncommunicable diseases, sub-Saharan Africans",
author = "Chilunga, {Felix P.} and Peter Henneman and Andrea Venema and Meeks, {Karlijn Ac} and Gonzalez, {Juan R.} and Carlos Ruiz-Arenas and Ana Requena-M{\'e}ndez and Erik Beune and Joachim Spranger and Liam Smeeth and Silver Bahendeka and Ellis Owusu-Dabo and Kerstin Klipstein-Grobusch and Adebowale Adeyemo and Mannens, {Marcel Mam} and Charles Agyemang",
note = "Funding Information: This work was supported by the European Commission under the Framework Programme (grant no.: 278901) and European Research Council Consolidation (grant no.: 772244). FP Chilunga is supported by the Erasmus Mundus Joint Doctorate Programme of the European Union through the Amsterdam Institute of Global Health and Development (AIGHD; grant agreement 2015– 1595). A.A. and K.A.C.M. are supported by the Intramural Research Program of the National Institutes of Health in the Center for Research on Genomics and Global Health (CRGGH). The CRGGH is supported by the National Human Genome Research Institute, the National Institute of Diabetes and Digestive and Kidney Diseases, the Center for Information Technology, and the Office of the Director at the National Institutes of Health (1ZIAHG200362). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. Publisher Copyright: {\textcopyright} 2021 Future Medicine Ltdl.",
year = "2021",
month = may,
day = "1",
doi = "https://doi.org/10.2217/epi-2020-0329",
language = "English",
volume = "13",
pages = "653--666",
journal = "Epigenomics",
issn = "1750-1911",
publisher = "Future Medicine Ltd.",
number = "9",
}