TY - JOUR
T1 - Donor sperm treatment
T2 - the role of semen parameters in intracervical insemination, a retrospective cohort study
AU - Kop, Petronella
AU - van Wely, Madelon
AU - de Melker, Annemieke
AU - van der Veen, Fulco
AU - Mochtar, Monique
N1 - Publisher Copyright: © 2022 The British Fertility Society.
PY - 2022
Y1 - 2022
N2 - Donor sperm treatment is advised to be performed with frozen-thawed donor semen. A disadvantage of frozen-thawed semen is lower pregnancy rates compared to inseminations with fresh semen. Semen parameters affect ongoing pregnancy rates in intracervical inseminations with frozen-thawed donor semen. In an attempt to translate this into clinical relevance, cohort studies have tried to find cut-off values for semen parameters after thawing for intracervical insemination, but these studies assessed only one semen parameter per study, thereby overlooking the intricate interplay between all semen parameters. We performed a retrospective cohort study and tried to calculate thresholds for all semen parameters that lead to the best possible ongoing pregnancy rates in intracervical insemination with frozen-thawed donor semen. Between April 1999 and December 2015, data from 1,186 women who underwent 7,103 cycles of intracervical insemination with donor semen from 129 sperm donors were available for analysis. Our results showed that total motility and total motile count (TMC) after thawing were associated with ongoing pregnancy rate. The best possible ongoing pregnancy chances after intracervical insemination were obtained at a total motility of ≥20% and a total motile count (TMC) of ≥8 × 106 after thawing.
AB - Donor sperm treatment is advised to be performed with frozen-thawed donor semen. A disadvantage of frozen-thawed semen is lower pregnancy rates compared to inseminations with fresh semen. Semen parameters affect ongoing pregnancy rates in intracervical inseminations with frozen-thawed donor semen. In an attempt to translate this into clinical relevance, cohort studies have tried to find cut-off values for semen parameters after thawing for intracervical insemination, but these studies assessed only one semen parameter per study, thereby overlooking the intricate interplay between all semen parameters. We performed a retrospective cohort study and tried to calculate thresholds for all semen parameters that lead to the best possible ongoing pregnancy rates in intracervical insemination with frozen-thawed donor semen. Between April 1999 and December 2015, data from 1,186 women who underwent 7,103 cycles of intracervical insemination with donor semen from 129 sperm donors were available for analysis. Our results showed that total motility and total motile count (TMC) after thawing were associated with ongoing pregnancy rate. The best possible ongoing pregnancy chances after intracervical insemination were obtained at a total motility of ≥20% and a total motile count (TMC) of ≥8 × 106 after thawing.
KW - Frozen
KW - donor semen
KW - intracervical insemination
KW - semen parameters
KW - thawed
UR - http://www.scopus.com/inward/record.url?scp=85124333449&partnerID=8YFLogxK
U2 - https://doi.org/10.1080/14647273.2022.2032407
DO - https://doi.org/10.1080/14647273.2022.2032407
M3 - Article
C2 - 35114884
SN - 1464-7273
JO - Human fertility (Cambridge, England)
JF - Human fertility (Cambridge, England)
ER -