Dopamine Receptor D-1/D-5 Gene Expression in the Medial Prefrontal Cortex Predicts Impulsive Choice in Rats

M. Loos, T. Pattij, M.C.W. Janssen, D.S. Counotte, A.N.M. Schoffelmeer, A.B. Smit, S. Spijker, M.M. van Gaalen

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

A neuropsychological hallmark of attention deficit/hyperactivity disorder (ADHD) is the reduced ability to tolerate delay of reinforcement, leading to impulsive choice. Genetic association studies have implicated several genes involved in dopaminergic neurotransmission in ADHD. In this study, we investigated whether differences in the expression level of these dopamine-related genes of rats predict the individual level of impulsive choice. Among all frontostriatal brain regions tested, only in the medial prefrontal cortex (mPFC), we observed significant positive correlations between impulsive choice and transcript levels of the dopamine receptor D1, the dopamine receptor D5 and calcyon. Local mPFC infusions of the D
Original languageEnglish
Pages (from-to)1064-1070
JournalCerebral cortex
Volume20
Issue number5
DOIs
Publication statusPublished - 2010

Cite this