Duty to recontact in genomic cancer care: A tool helping to assess the professional's responsibility

Martine C. Ploem; Noor A. A. Giesbertz; Annelien L. Bredenoord; Valesca P. Retèl; Wim H. van Harten

doi:https://doi.org/10.1016/j.ejca.2023.03.004

Duty to recontact in genomic cancer care: A tool helping to assess the professional's responsibility

Martine C. Ploem, Noor A. A. Giesbertz, Annelien L. Bredenoord, Valesca P. Retèl, Wim H. van Harten

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Tumour DNA and germline testing, based on DNA-wide sequencing analysis, are becoming more and more routine in clinical-oncology practice. A promising step in medicine, but at the same time leading to challenging ethicolegal questions. An important one is under what conditions individuals (patients and their relatives, research participants) should be recontacted with new information, even if many years have passed since the last contact. Based on legal- and ethical study, we developed a tool to help professionals to decide whether or not to recontact an individual in specific cases. It is based on four assessment criteria: (1) professional relationship (2) clinical impact (3) individual's preferences and (4) feasibility. The tool could also serve as a framework for guidelines on the topic.

Original language	English
Pages (from-to)	22-26
Number of pages	5
Journal	European Journal of Cancer
Volume	186
Early online date	3 Mar 2023
DOIs	https://doi.org/10.1016/j.ejca.2023.03.004
Publication status	Published - 1 Jun 2023

Keywords

Duty to recontact
Ethics
Genomic testing
Legislation
Responsibility
Whole genome sequencing

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https://doi.org/10.1016/j.ejca.2023.03.004

Cite this

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title = "Duty to recontact in genomic cancer care: A tool helping to assess the professional's responsibility",

abstract = "Tumour DNA and germline testing, based on DNA-wide sequencing analysis, are becoming more and more routine in clinical-oncology practice. A promising step in medicine, but at the same time leading to challenging ethicolegal questions. An important one is under what conditions individuals (patients and their relatives, research participants) should be recontacted with new information, even if many years have passed since the last contact. Based on legal- and ethical study, we developed a tool to help professionals to decide whether or not to recontact an individual in specific cases. It is based on four assessment criteria: (1) professional relationship (2) clinical impact (3) individual's preferences and (4) feasibility. The tool could also serve as a framework for guidelines on the topic.",

keywords = "Duty to recontact, Ethics, Genomic testing, Legislation, Responsibility, Whole genome sequencing",

author = "Ploem, {Martine C.} and Giesbertz, {Noor A. A.} and Bredenoord, {Annelien L.} and Ret{\`e}l, {Valesca P.} and {van Harten}, {Wim H.}",

note = "Funding Information: We acknowledge Prof. Dr. S.C. Linn for reading through the manuscript and providing us with valuable input. This study was performed as a part of the “Technology Assessment of Next Generation Sequencing in Personalized Oncology (TANGO)” project, funded by ZonMW, (The Netherlands Organisation for Health Research and Development) #846001002. Funding Information: This study was performed as a part of the “Technology Assessment of Next Generation Sequencing in Personalized Oncology ( TANGO )” project, funded by ZonMW , (The Netherlands Organisation for Health Research and Development) #846001002 . Publisher Copyright: {\textcopyright} 2023 The Authors",

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doi = "https://doi.org/10.1016/j.ejca.2023.03.004",

language = "English",

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AU - Retèl, Valesca P.

AU - van Harten, Wim H.

N1 - Funding Information: We acknowledge Prof. Dr. S.C. Linn for reading through the manuscript and providing us with valuable input. This study was performed as a part of the “Technology Assessment of Next Generation Sequencing in Personalized Oncology (TANGO)” project, funded by ZonMW, (The Netherlands Organisation for Health Research and Development) #846001002. Funding Information: This study was performed as a part of the “Technology Assessment of Next Generation Sequencing in Personalized Oncology ( TANGO )” project, funded by ZonMW , (The Netherlands Organisation for Health Research and Development) #846001002 . Publisher Copyright: © 2023 The Authors

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Duty to recontact in genomic cancer care: A tool helping to assess the professional's responsibility

Abstract

Keywords

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