Dye-Based Chromoendoscopy in Patients With Lynch Syndrome: An Individual Patient Data Meta-Analysis of Randomized Trials

Britt B. S. L. Houwen, Nahid Mostafavi, Jasper L. A. Vleugels, Robert Hüneburg, Christof Lamberti, Liseth Rivero-Sánchez, María Pellisé, Elena M. Stoffel, Sapna Syngal, Jasmijn F. Haanstra, Jan J. Koornstra, Evelien Dekker, Yark Hazewinkel

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4 Citations (Scopus)


INTRODUCTION: The additional diagnostic value of dye-based chromoendosocpy (CE) for surveillance of patients with Lynch syndrome is subject of debate. METHODS: To clarify this debate, we performed an individual patient data meta-analysis of randomized studies that compared CE with WLE for the detection of adenomas in patients with Lynch syndrome. RESULTS: Three randomized studies comprising 533 patients were included. The adenoma detection rate was 74/265 (28%) in patients randomized to WLE compared with 83/266 (31%) in patients randomized to CE (odds ratio 1.17; 95% confidence interval 0.81-1.70). DISCUSSION: Based on low-quality evidence, CE showed no apparent increase in adenoma detection compared to WLE during surveillance of patients with Lynch syndrome.
Original languageEnglish
Pages (from-to)825-828
Number of pages4
JournalAmerican Journal of Gastroenterology
Issue number4
Publication statusPublished - 1 Apr 2021

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