TY - JOUR
T1 - Dyslipidemia of Mothers With Familial Hypercholesterolemia Deteriorates Lipids in Adult Offspring
AU - van der Graaf, Anouk
AU - Vissers, Maud N.
AU - Gaudet, Daniel
AU - Brisson, Diane
AU - Sivapalaratnam, Suthesh
AU - Roseboom, Tessa J.
AU - Jansen, Angelique C. M.
AU - Kastelein, John J. P.
AU - Hutten, Barbara A.
PY - 2010
Y1 - 2010
N2 - Objective-It is unknown whether elevated maternal low-density lipoprotein cholesterol (LDL-C) levels lead to dyslipidemia in the offspring. Because this could have important consequences for cardiovascular prevention in mother and child, we explored the relationship between maternal familial hypercholesterolemia (FH) and lipids in adult offspring. Methods and Results-In a large cohort of both Dutch and Canadian origin, we compared lipid profiles between patients, aged 18 to 85 years, who inherited FH maternally (n = 1069) and those who inherited FH paternally (n = 1270). This relationship was evaluated using multivariate regression analyses. Levels of total cholesterol (TC), LDL-C, and apolipoprotein B 100 (ApoB100) were significantly elevated in patients who inherited FH maternally compared with patients who inherited FH paternally (adjusted differences in TC: 0.156 mmol/L, P = 0.037; LDL-C: 0.187 mmol/L, P = 0.012; ApoB: 0.064 g/L, P = 0.022). Conclusion-Our data show that maternal hereditary hypercholesterolemia slightly increases TC, LDL-C, and ApoB levels in their offspring later in life. Although the molecular mechanisms underlying these observations still require elucidation, our data suggest that maternal hypercholesterolemia during pregnancy may program lipid metabolism to a certain extent in the fetus. (Arterioscler Thromb Vasc Biol. 2010;30:2673-2677.)
AB - Objective-It is unknown whether elevated maternal low-density lipoprotein cholesterol (LDL-C) levels lead to dyslipidemia in the offspring. Because this could have important consequences for cardiovascular prevention in mother and child, we explored the relationship between maternal familial hypercholesterolemia (FH) and lipids in adult offspring. Methods and Results-In a large cohort of both Dutch and Canadian origin, we compared lipid profiles between patients, aged 18 to 85 years, who inherited FH maternally (n = 1069) and those who inherited FH paternally (n = 1270). This relationship was evaluated using multivariate regression analyses. Levels of total cholesterol (TC), LDL-C, and apolipoprotein B 100 (ApoB100) were significantly elevated in patients who inherited FH maternally compared with patients who inherited FH paternally (adjusted differences in TC: 0.156 mmol/L, P = 0.037; LDL-C: 0.187 mmol/L, P = 0.012; ApoB: 0.064 g/L, P = 0.022). Conclusion-Our data show that maternal hereditary hypercholesterolemia slightly increases TC, LDL-C, and ApoB levels in their offspring later in life. Although the molecular mechanisms underlying these observations still require elucidation, our data suggest that maternal hypercholesterolemia during pregnancy may program lipid metabolism to a certain extent in the fetus. (Arterioscler Thromb Vasc Biol. 2010;30:2673-2677.)
U2 - https://doi.org/10.1161/ATVBAHA.110.209064
DO - https://doi.org/10.1161/ATVBAHA.110.209064
M3 - Article
C2 - 20864670
SN - 1079-5642
VL - 30
SP - 2673-U623
JO - Arteriosclerosis, Thrombosis, and Vascular Biology
JF - Arteriosclerosis, Thrombosis, and Vascular Biology
IS - 12
ER -