TY - JOUR
T1 - The course of health-related quality of life from diagnosis to two years follow-up in patients with oropharyngeal cancer
T2 - does HPV status matter?
AU - Korsten, Laura H A
AU - Jansen, Femke
AU - Lissenberg-Witte, Birgit I
AU - Vergeer, Marije
AU - Brakenhoff, Ruud H
AU - Leemans, C René
AU - Verdonck-de Leeuw, Irma M
N1 - Funding Information: Dr. Verdonck-de Leeuw reported receiving grants from KWF Kankerbestrijding, ZonMw, Bristol-Myers Squibb. No other disclosures were reported. Funding Information: This work was supported by the Dutch Cancer Society under Grant VU 2013–5930. Publisher Copyright: © 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/8/1
Y1 - 2021/8/1
N2 - PURPOSE: To investigate the course of health-related quality of life (HRQOL) from diagnosis to 2 years follow-up among patients with oropharyngeal cancer (OPSCC), in relation to human papilloma virus (HPV) status.METHODS: This study included 270 OPSCC patients. Age, sex, tumor sublocation, tumor stage, HPV status, treatment modality, comorbidity, smoking, and alcohol use were retrieved from medical records. HPV status was positive when p16 and HPV DNA tests were both positive. HRQOL was assessed using the EORTC QLQ-C30/QLQ-H&N35 pretreatment and at 6 weeks, 6, 12, 18, and 24 months after treatment. To compare the course of HRQOL between patients with an HPV-positive versus HPV-negative tumor, linear and logistic mixed models were used.RESULTS: Patients with an HPV-positive tumor (29%) were more often male, diagnosed with a tumor of the tonsil or base of the tongue, treated with single treatment, had fewer comorbidities, were less often current smokers and had lower alcohol consumption. Adjusted for confounders, the course of global quality of life, physical, role, and social functioning, fatigue, pain, insomnia, and appetite loss was significantly different: patients with an HPV-positive tumor scored better before treatment, worsened during treatment, and recovered better and faster at follow-up, compared to patients with an HPV-negative tumor. The course of emotional functioning and oral pain was also significantly different between the two groups, but with other trajectories.CONCLUSION: The course of HRQOL is different in patients with an HPV-positive tumor versus an HPV-negative tumor, adjusted for sociodemographic, clinical, and lifestyle confounders.
AB - PURPOSE: To investigate the course of health-related quality of life (HRQOL) from diagnosis to 2 years follow-up among patients with oropharyngeal cancer (OPSCC), in relation to human papilloma virus (HPV) status.METHODS: This study included 270 OPSCC patients. Age, sex, tumor sublocation, tumor stage, HPV status, treatment modality, comorbidity, smoking, and alcohol use were retrieved from medical records. HPV status was positive when p16 and HPV DNA tests were both positive. HRQOL was assessed using the EORTC QLQ-C30/QLQ-H&N35 pretreatment and at 6 weeks, 6, 12, 18, and 24 months after treatment. To compare the course of HRQOL between patients with an HPV-positive versus HPV-negative tumor, linear and logistic mixed models were used.RESULTS: Patients with an HPV-positive tumor (29%) were more often male, diagnosed with a tumor of the tonsil or base of the tongue, treated with single treatment, had fewer comorbidities, were less often current smokers and had lower alcohol consumption. Adjusted for confounders, the course of global quality of life, physical, role, and social functioning, fatigue, pain, insomnia, and appetite loss was significantly different: patients with an HPV-positive tumor scored better before treatment, worsened during treatment, and recovered better and faster at follow-up, compared to patients with an HPV-negative tumor. The course of emotional functioning and oral pain was also significantly different between the two groups, but with other trajectories.CONCLUSION: The course of HRQOL is different in patients with an HPV-positive tumor versus an HPV-negative tumor, adjusted for sociodemographic, clinical, and lifestyle confounders.
KW - Cohort study
KW - HPV
KW - Head and neck cancer
KW - Health-related quality of life
KW - Human papilloma virus
KW - Oropharyngeal cancer
UR - http://www.scopus.com/inward/record.url?scp=85100217933&partnerID=8YFLogxK
U2 - https://doi.org/10.1007/s00520-020-05932-w
DO - https://doi.org/10.1007/s00520-020-05932-w
M3 - Article
C2 - 33454834
SN - 0941-4355
VL - 29
SP - 4473
EP - 4483
JO - Supportive Care in Cancer
JF - Supportive Care in Cancer
IS - 8
ER -