Clonal Patterns Between Pouch Neoplasia and Prior Colorectal Neoplasia in Inflammatory Bowel Disease Patients: An Exploratory Cohort Study

Maarten te Groen, Lauranne A. A. P. Derikx, Lisa van Lierop, Bauke Ylstra, Frank Hoentjen, Iris D. Nagtegaal, Femke Simmer

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Prior colorectal neoplasia is the strongest predictor of pouch neoplasia in inflammatory bowel disease, but the underlying mechanism is unknown. We observed clonality between colorectal and pouch neoplasia in 30% of patients, indicating that most pouch neoplasia develops clonally independent from prior colorectal lesions.

Original languageEnglish
Pages (from-to)1347-1351
Number of pages5
JournalInflammatory Bowel Diseases
Volume29
Issue number8
DOIs
Publication statusPublished - 1 Aug 2023

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